Evidence map›Paper›PMID 28885690›Full record

ArticleJournal of cellular physiology2018

Global analysis of gene expression profiles in the submandibular salivary gland of klotho knockout mice.

Sung-Min Kwon, Soo-A Kim, Jung-Hoon Yoon, Jong-In Yook, Sang-Gun Ahn

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Sung-Min KwonDepartment of Oral and Maxillofacial Pathology, College of Dentistry, Wonkwang University, Daejeon, Republic of Korea.
Soo-A KimDepartment of Biochemistry, College of Oriental Medicine, Dongguk University, Gyeongju, Republic of Korea.
Jung-Hoon YoonDepartment of Oral and Maxillofacial Pathology, College of Dentistry, Wonkwang University, Daejeon, Republic of Korea.
Jong-In YookDepartment of Oral Pathology, Yonsei University College of Dentistry, Seoul, Republic of Korea.
Sang-Gun AhnDepartment of Pathology, College of Dentistry, Chosun University, Gwangju, Republic of Korea.ORCID 0000-0002-5837-7527
Wonkwang University · KRChosun University · KRDongguk University · KRYonsei University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Salivary dysfunction commonly occurs in many older adults and is considered a physiological phenomenon. However, the genetic changes in salivary glands during aging have not been characterized. The present study analyzed the gene expression profile in salivary glands from accelerated aging klotho deficient mice (klotho-/-, 4 weeks old). Microarray analysis showed that 195 genes were differentially expressed (z-score > 2 in two independent arrays) in klotho null mice compared to wild-type mice. Importantly, alpha2-Na

Indexed as

Gene Expression ProfilingAgingAnimalsDown-RegulationGene OntologyGene Regulatory NetworksGlucuronidaseHumansKlotho ProteinsMice, KnockoutOligonucleotide Array Sequence AnalysisPPAR gammaReproducibility of ResultsSignal TransductionSubmandibular GlandTongueGlucuronidaseKlotho ProteinsPPAR gammaTranscription Factorsaginggene profilingklothosalivary gland

Identifiers

PMID28885690
PMCPMC5765504
OpenAlexW2753664364

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.