ReviewNature reviews. Endocrinology2018
Primary hyperparathyroidism.
Review in Nature reviews. Endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03931109 (Circulating microRNA Signatures in Primary Hyperparathyroidism), which is not on this map. Cited by 303 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Circulating microRNA Signatures in Primary Hyperparathyroidism
Who cites it
303 citing papers in PubMed, 4 syntheses or guidelines pooled it, 537 citations in OpenAlex.
- Percutaneous microwave ablation of hyperfunctioning parathyroid lesions under multiparametric ultrasound guidance for primary hyperparathyroidism: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- Quality appraisal of clinical practice guidelines for the evaluation and management of primary hyperparathyroidism.Endocrine · 2024Pooled it
- Risk of Malignant Neoplasm in Patients with Primary Hyperparathyroidism: A Systematic Review and Meta-analysis.Calcified tissue international · 2024Pooled it
- Italian Guidelines for the Management of Sporadic Primary Hyperparathyroidism.Endocrine, metabolic & immune disorders drug targets · 2024Guideline
- Comparison of the two treatment methods in primary hyperparathyroidism due to solitary parathyroid adenoma, Ultrasound-guided percutaneous alcohol ablation vs. parathyroidectomy: a randomized controlled trial.BMC endocrine disorders · 2025Trial
- Multimodality imaging localization of a giant functional parathyroid adenoma in a young fitness trainer with delayed recognition of hypercalcemia: A case report.Radiology case reports · 2026Article
- Textbook outcome in surgery for primary hyperparathyroidism: first steps toward a composite quality metric.Updates in surgery · 2026Article
- Evaluating the preoperative diagnostic value ofJournal of applied clinical medical physics · 2026Article
- Beyond conventional maging: the diagnostic performance of [Annals of nuclear medicine · 2026Article
- Cardiovascular Alterations in Primary Hyperparathyroidism: Associations with Risk Profile, Cardiac Structure, and Function.Journal of clinical medicine · 2026Article
- Normo-hormonal primary hyperparathyroidism presenting with recurrent acute pancreatitis.JCEM case reports · 2026Article
- Clinical outcomes of parathyroidectomy in primary hyperparathyroidism: a 10-year single-center experience with 115 procedures.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Slice Level Classification of Parathyroid Adenoma Using Arterial Phase CT Images with Hybrid Light Attention Mechanism Based Residual Framework.Bioengineering (Basel, Switzerland) · 2026Article
- Diagnostic Contribution of SPECT/CT to Dual-PhaseBiomedicines · 2026Article
- Challenges and unmet needs of [European journal of nuclear medicine and molecular imaging · 2026Article
- Do Biochemical Markers Reflect Parathyroid Adenoma Volume in Primary Hyperparathyroidism?International journal of molecular sciences · 2026Article
- Long-term outcomes and prognostic factors following microwave ablation vs surgical resection for primary hyperparathyroidism.European radiology · 2026Article
- Preoperative imaging strategies to optimize surgical treatment in primary hyperparathyroidism (pHPT).BMC surgery · 2026Article
- Prevalence and determinants of secondary hyperparathyroidism: IMOS-2021.Scientific reports · 2026Article
- Autotransplanted parathyroid adenoma as a rare cause of primary hyperparathyroidism: focused literature review.Irish journal of medical science · 2026Review
243 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In this Review, we describe the pathogenesis, diagnosis and management of primary hyperparathyroidism (PHPT), with a focus on recent advances in the field. PHPT is a common endocrine disorder that is characterized by hypercalcaemia and elevated or inappropriately normal serum levels of parathyroid hormone. Most often, the presentation of PHPT is asymptomatic in regions of the world where serum levels of calcium are routinely measured. In addition to mild hypercalcaemia, PHPT can manifest with osteoporosis and hypercalciuria as well as with vertebral fractures and nephrolithiasis, both of which can be asymptomatic. Other clinical forms of PHPT, such as classical disease and normocalcaemic PHPT, are less common. Parathyroidectomy, the only curative treatment for PHPT, is recommended in patients with symptoms and those with asymptomatic disease who are at risk of progression or have subclinical evidence of end-organ sequelae. Parathyroidectomy results in an increase in BMD and a reduction in nephrolithiasis. Various medical therapies can increase BMD or reduce serum levels of calcium, but no single drug can do both. More data are needed regarding the neuropsychological manifestations of PHPT and the pathogenetic mechanisms leading to sporadic PHPT, as well as on risk factors for complications of the disorder. Future work that advances our knowledge in these areas will improve the management of the disorder.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.