Evidence map›Paper›PMID 28885548›Full record

ArticleInternational journal of molecular sciences2017

Novel Insights into the Adipokinome of Obese and Obese/Diabetic Mouse Models.

Birgit Knebel, Simon Goeddeke, Gereon Poschmann, Daniel F Markgraf, Sylvia Jacob, Ulrike Nitzgen, Waltraud Passlack, Christina Preuss, Hans-Dieter Dicken, Kai Stühler and 3 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Nutrients · 2020
    Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Birgit KnebelInstitute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Heinrich-Heine-University Duesseldorf, Leibniz Center for Diabetes Research, Aufm Hennekamp 65, 40225 Dusseldorf, Germany. bknebel@ddz.uni-duesseldorf.de.
Simon GoeddekeInstitute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Heinrich-Heine-University Duesseldorf, Leibniz Center for Diabetes Research, Aufm Hennekamp 65, 40225 Dusseldorf, Germany. simon.goeddeke@ddz.uni-duesseldorf.de.
Gereon PoschmannMolecular Proteomics Laboratory, Biomedizinisches Forschungszentrum (BMFZ), Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany. gereon.poschmann@hhu.de.
Daniel F MarkgrafGerman Center for Diabetes Research (DZD), Partner Duesseldorf, 40225 Duesseldorf, Germany. daniel.markgraf@ddz.uni-duesseldorf.de.
Sylvia JacobInstitute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Heinrich-Heine-University Duesseldorf, Leibniz Center for Diabetes Research, Aufm Hennekamp 65, 40225 Dusseldorf, Germany. sylvia.jacob@ddz.uni-duesseldorf.de.
Ulrike NitzgenInstitute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Heinrich-Heine-University Duesseldorf, Leibniz Center for Diabetes Research, Aufm Hennekamp 65, 40225 Dusseldorf, Germany. ulrike.nitzgen@ddz.uni-duesseldorf.de.
Waltraud PasslackInstitute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Heinrich-Heine-University Duesseldorf, Leibniz Center for Diabetes Research, Aufm Hennekamp 65, 40225 Dusseldorf, Germany. waltraud.passlack@ddz.uni-duesseldorf.de.
Christina PreussGerman Center for Diabetes Research (DZD), Partner Duesseldorf, 40225 Duesseldorf, Germany. christina.preuss@ddz.uni-duesseldorf.de.ORCID 0000-0001-6552-5826
Hans-Dieter DickenMultimedia Center, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany. hans-dieter.dicken@uni-duesseldorf.de.
Kai StühlerMolecular Proteomics Laboratory, Biomedizinisches Forschungszentrum (BMFZ), Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany. kai.stuehler@hhu.de.
Sonja HartwigInstitute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Heinrich-Heine-University Duesseldorf, Leibniz Center for Diabetes Research, Aufm Hennekamp 65, 40225 Dusseldorf, Germany. sonja.hartwig@ddz.uni-duesseldorf.de.
Stefan LehrInstitute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Heinrich-Heine-University Duesseldorf, Leibniz Center for Diabetes Research, Aufm Hennekamp 65, 40225 Dusseldorf, Germany. stefan.lehr@ddz.uni-duesseldorf.de.
Jorg KotzkaInstitute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Heinrich-Heine-University Duesseldorf, Leibniz Center for Diabetes Research, Aufm Hennekamp 65, 40225 Dusseldorf, Germany. jkotzka@ddz.uni-duesseldorf.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The group of adipokines comprises hundreds of biological active proteins and peptides released from adipose tissue. Alterations of those complex protein signatures are suggested to play a crucial role in the pathophysiology of multifactorial, metabolic diseases. We hypothesized that also the pathophysiology of type-2-diabetes is linked to the dysregulation of the adipocyte secretome. To test this, we investigated mouse models with monogenic defects in leptin signaling which are susceptible to adipositas (C57BL/6 Cg-Lep

Indexed as

ProteomicsAdipocytesAdipokinesAdipose TissueAnimalsBiomarkersCluster AnalysisDiabetes Mellitus, Type 2Disease Models, AnimalLipid MetabolismMaleMass SpectrometryMiceMice, ObeseObesityProteomeAdipokinesBiomarkersProteomediabetes and obesitydiacylglycerolhealthy adipose tissuemass spectrometryprimary adipocyte

Identifiers

PMID28885548
PMCPMC5618577

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.