ArticleMedicine2017
Acute versus subacute community-acquired meningitis: Analysis of 611 patients.
Article in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Enhancing meningitis diagnosis: a diagnostic stewardship workflow in a resource-limited setting.Microbiology spectrum · 2026Article
- Review
- Article
- Chronic Headache and Visual Field Loss: Manifestations in a Patient With ChronicCase reports in infectious diseases · 2026Article
- Burden of meningitis and encephalitis in Iran from 1990 to 2021: findings from the Global Burden of Disease study.BMC neurology · 2025Article
- A Multiplex Polymerase Chain Reaction Assay for the Detection of Herpes Simplex Virus, Cytomegalovirus, and Varicella-Zoster Virus in Cerebrospinal Fluid.Microorganisms · 2025Article
- Clinical application and evaluation of metagenomic next-generation sequencing in pathogen detection for suspected central nervous system infections.Scientific reports · 2024Article
- Autoimmune glial fibrillar acidic protein astrocytopathy mimicking tuberculous meningitis.BMJ case reports · 2022Article
- Diagnostic and therapeutic approach to chronic meningitis in Brazil: a narrative review.Arquivos de neuro-psiquiatria · 2022Review
- Evaluation of the epidemiologic, clinical, radiologic, and treatment methods of patients with subacute and chronic meningitis.BMC neurology · 2022Article
- Heparin-Binding Protein (HBP), Neutrophil Gelatinase-Associated Lipocalin (NGAL) and S100 Calcium-Binding Protein B (S100B) Can Confirm Bacterial Meningitis and Inform Adequate Antibiotic Treatment.Antibiotics (Basel, Switzerland) · 2022Article
- Dynamics of community-acquired meningitis syndrome outbreaks in southern France.Frontiers in microbiology · 2022Article
- Rare case ofBMJ case reports · 2021Article
- Tuberculous Meningitis: Pathogenesis, Immune Responses, Diagnostic Challenges, and the Potential of Biomarker-Based Approaches.Journal of clinical microbiology · 2021Review
- Inflammatory Disease Affecting the Central Nervous System in Dogs: A Retrospective Study in England (2010-2019).Frontiers in veterinary science · 2021Article
- The diagnostic utility of the "Thwaites' system" and "lancet consensus scoring system" in tuberculous vs. non-tuberculous subacute and chronic meningitis: multicenter analysis of 395 adult patients.BMC infectious diseases · 2020Article
- Methods for rapid diagnosis of meningitis etiology in adults.Biomarkers in medicine · 2020Review
- The Use of Adjunctive Steroids in Central Nervous Infections.Frontiers in cellular and infection microbiology · 2020Review
- Direct-from-Specimen Pathogen Identification: Evolution of Syndromic Panels.Clinics in laboratory medicine · 2019Review
- Clinicopathology conference: 41-year-old woman with chronic relapsing meningitis.Annals of neurology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Community-acquired meningitis can be classified into acute and subacute presentations by the duration of illness of ≤ or >5 days, respectively. There are currently no studies comparing the clinical features, management decisions, etiologies, and outcomes between acute and subacute presentations.It is a retrospective study of adults with community-acquired meningitis hospitalized in Houston, TX between January 2005 and January 2010. An adverse clinical outcome was defined as a Glasgow Outcome Scale score of ≤4.A total of 611 patients were identified, of which 458 (75%) were acute and 153 subacute (25%). The most common etiologies were unknown in 418 (68.4%), viral in 94 (15.4%), bacterial in 47 (7.7%), fungal in 42 patients (6.9%), and other noninfectious etiologies in 6 (1%). Patients with subacute meningitis were more likely to be immunosuppressed or have comorbidities, had fungal etiologies, and had higher rates of hypoglycorrachia and abnormal neurological findings (P <.05). Patients with an acute presentation were more likely to be treated empirically with intravenous antibiotics and had higher cerebrospinal fluid pleocytosis and serum white blood cell counts (P <.05). On logistic regression, age >65 years and abnormal neurological findings were predictive of an adverse clinical outcome in both acute and subacute meningitis, whereas fever was also a significant prognostic factor in acute meningitis. (P <.05).Acute and subacute meningitis differ in regards to clinical presentations, etiologies, laboratory findings, and management decisions, but did not differ in rates of adverse clinical outcomes. Future studies including thoroughly investigated patients with new diagnostic molecular methods may show different results and outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.