ArticleActa oncologica (Stockholm, Sweden)2017
Spatial rectal dose/volume metrics predict patient-reported gastro-intestinal symptoms after radiotherapy for prostate cancer.
Article in Acta oncologica (Stockholm, Sweden), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Fecal incontinence after prostate cancer irradiation: a systematic literature review.Prostate cancer and prostatic diseases · 2026Pooled it
- Exploring the role of health-related quality of life measures in predictive modelling for oncology: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Pooled it
- Development of a spatially indexed dose-volume histogram for treatment plan evaluation.Journal of radiation research · 2026Article
- Predictive Factors for Gastrointestinal and Genitourinary Toxicities in Prostate Cancer External Beam Radiotherapy: A Scoping Review.Diagnostics (Basel, Switzerland) · 2025Review
- Relationship Between Radiation Therapy and Fecal Incontinence in Patients Treated for Localized Prostate Cancer: Results of the French ICONES Study.The Prostate · 2025Article
- Selective sparing of bladder and rectum sub-regions in radiotherapy of prostate cancer combining knowledge-based automatic planning and multicriteria optimization.Physics and imaging in radiation oncology · 2023Article
- Normal tissue complication probability models for prospectively scored late rectal and urinary morbidity after proton therapy of prostate cancer.Physics and imaging in radiation oncology · 2021Article
- Radiotherapy-Induced Digestive Injury: Diagnosis, Treatment and Mechanisms.Frontiers in oncology · 2021Review
- Associations between voxel-level accumulated dose and rectal toxicity in prostate radiotherapy.Physics and imaging in radiation oncology · 2020Article
- Local Dose Effects for Late Gastrointestinal Toxicity After Hypofractionated and Conventionally Fractionated Modern Radiotherapy for Prostate Cancer in the HYPRO Trial.Frontiers in oncology · 2020Article
- Adapting training for medical physicists to match future trends in radiation oncology.Physics and imaging in radiation oncology · 2019Article
- Dose/Volume histogram patterns in Salivary Gland subvolumes influence xerostomia injury and recovery.Scientific reports · 2019Article
- Comparison of relative and absolute rectal dose-volume parameters and clinical correlation with acute and late radiation proctitis in prostate cancer patients.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2019Article
- PACE: A Probabilistic Atlas for Normal Tissue Complication Estimation in Radiation Oncology.Frontiers in oncology · 2019Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundGastro-intestinal (GI) toxicity after radiotherapy (RT) for prostate cancer reduces patient's quality of life. In this study, we explored associations between spatial rectal dose/volume metrics and patient-reported GI symptoms after RT for localized prostate cancer, and compared these with those of dose-surface/volume histogram (DSH/DVH) metrics. MATERIAL AND
methodsDose distributions and six GI symptoms (defecation urgency/emptying difficulties/fecal leakage, ≥Grade 2, median follow-up: 3.6 y) were extracted for 200 patients treated with image-guided RT in 2005-2007. Three hundred and nine metrics assessed from 2D rectal dose maps or DSHs/DVHs were subject to 50-times iterated five-fold cross-validated univariate and multivariate logistic regression analysis (UVA, MVA). Performance of the most frequently selected MVA models was evaluated by the area under the receiving-operating characteristics curve (AUC).
resultsThe AUC increased for dose-map compared to DSH/DVH-based models (mean SD: 0.64 ± 0.03 vs. 0.61 ± 0.01), and significant relations were found for six versus four symptoms. Defecation urgency and faecal leakage were explained by high doses at the central/upper and central areas, respectively; while emptying difficulties were explained by longitudinal extensions of intermediate doses.
conclusionsPredictability of patient-reported GI toxicity increased using spatial metrics compared to DSH/DVH metrics. Novel associations were particularly identified for emptying difficulties using both approaches in which intermediate doses were emphasized.
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