ArticleJournal of clinical neurology (Seoul, Korea)2017
Effects of Antiepileptic Drugs on the Carotid Artery Intima-Media Thickness in Epileptic Patients.
Article in Journal of clinical neurology (Seoul, Korea), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 27 citations in OpenAlex.
- Management recommendations to reduce cardiac risk in chronic epilepsy.Epilepsy & behavior reports · 2025Review
- Antiseizure Medications and Cardiovascular Events in Older People With Epilepsy in the Canadian Longitudinal Study on Aging.JAMA neurology · 2024Article
- Epilepsy and the risk of adverse cardiovascular events: A nationwide cohort study.European journal of neurology · 2024Article
- The Epileptic Heart Syndrome: Epidemiology, pathophysiology and clinical detection.Epilepsy & behavior reports · 2024Article
- Comparison of myocardial perfusion between the users of two antiepileptic medications: valproate vs. carbamazepine.Asia Oceania journal of nuclear medicine & biology · 2023Article
- Influence of Different Antiseizure Medications on Vascular Risk Factors in Children with Epilepsy.Children (Basel, Switzerland) · 2022Article
- Comment on "Role of Mitochondrial Genome Mutations in Pathogenesis of Carotid Atherosclerosis".Oxidative medicine and cellular longevity · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeIt has been reported that taking antiepileptic drugs (AEDs) may increase the risk of atherosclerosis. We performed a meta-analysis to evaluate the carotid artery intima-media thickness (CA-IMT) as a surrogate factor for atherosclerosis in epileptic patients.
methodsWe searched NCBI (PubMed), ISI Web of Knowledge, EMBASE, and the Cochrane Library databases for studies of the association between AEDs and CA-IMT in epileptic patients. A random-effects meta-analysis was used to pool results across studies.
resultsFifteen studies involving 1,775 epileptic patients were included in the analysis. The overall CA-IMT was significantly larger among users of AEDs [mean difference (MD)=0.09 mm, 95% confidence interval (CI)=0.06-0.12 mm). When stratified by age, the MD was similar in adult patients (MD=0.09 mm, 95% CI=0.06-0.13 mm), but no significant difference was observed in children (MD=0.03 mm, 95% CI=0.00-0.07 mm). Regarding specific AEDs, monotherapy with carbamazepine (CBZ) or valproic acid (VPA) was associated with a larger CA-IMT, while phenytoin monotherapy was not and the result for lamotrigine was inconclusive.
conclusionsThis study suggests that using AEDs is associated with the CA-IMT in patients with epilepsy, particularly for adult patients. In particular, CBZ and VPA may be related to a significant increase in CA-IMT.
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