Evidence map›Paper›PMID 28884793›Full record

ArticleCurrent protocols in mouse biology2017

Using Vascular Landmarks to Orient 3D Optical Coherence Tomography Images of the Mouse Eye.

Mark P Krebs

Abstract read
In one paragraph

Article in Current protocols in mouse biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Mark P KrebsThe Jackson Laboratory, Bar Harbor, Maine.

Funding

RETINAL DISEASE: MOLECULAR BASIS AND PATHOPHYSIOLOGYR01EY011996 · NEI · JACKSON LABORATORY · PI Patsy M Nishina · 1998 to 2026
$12.4M
Mouse Models for Vision ResearchR01EY016501 · NEI · JACKSON LABORATORY · PI NISHINA, PATSY M · 2005 to 2014
$9.4M
Identifying Shared Pathogenic Networks and Molecular Targets Underlying Retinal Pigmented Epithelial Associated DiseaseR01EY027860 · NEI · JACKSON LABORATORY · PI CARTER, GREGORY W, NISHINA, PATSY M · 2017 to 2020
$2.4M
NEI NIH HHS R01 EY011996NEI NIH HHS R01 EY016501NEI NIH HHS R01 EY027860
6 · The paper itself

Abstract

Comparing 3D structural information obtained by optical coherence tomography (OCT) requires accurate alignment of images acquired from individual subjects. Despite the widespread use of OCT to image the anterior and posterior mouse eye, few approaches to align the resulting image data have been described, in part due to a lack of well-characterized landmarks that are suitable for alignment. Here, we provide an OCT acquisition and analysis protocol that incorporates the use of the long posterior ciliary arteries as landmarks. In mammals, these two large choroidal vessels lie in a plane approximately parallel to the horizon. Our OCT imaging approach resolves these vessels in the mouse eye and suggests that their location is reproducible. The protocol may be useful for preparing 3D OCT data to compare experimental cohorts of mice and for standardizing results from independent research laboratories. © 2017 by John Wiley & Sons, Inc.

Indexed as

Imaging, Three-DimensionalAnimalsChoroidCiliary ArteriesMiceTomography, Optical Coherenceatlas landmarksFiji/ImageJ analysismouse modelsnoninvasive imagingoptical coherence tomography

Identifiers

PMID28884793
PMCPMC5657575

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.