ArticleEvolution; international journal of organic evolution2017
Fitness change in relation to mutation number in spontaneous mutation accumulation lines of Chlamydomonas reinhardtii.
Article in Evolution; international journal of organic evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed.
- The Effects of De Novo Mutation on Gene Expression and the Consequences for Fitness in Chlamydomonas reinhardtii.Molecular biology and evolution · 2024Article
- Genus-Wide Transcriptional Landscapes Reveal Correlated Gene Networks Underlying Microevolutionary Divergence in Diatoms.Molecular biology and evolution · 2023Article
- Rates and spectra of de novo structural mutations inGenome research · 2023Article
- Selection in a growing colony biases results of mutation accumulation experiments.Scientific reports · 2022Article
- Fitness Effects of Mutations: An Assessment of PROVEAN Predictions Using Mutation Accumulation Data.Genome biology and evolution · 2022Article
- Precise measurement of the fitness effects of spontaneous mutations by droplet digital PCR in Burkholderia cenocepacia.Genetics · 2021Article
- De Novo Mutation Rate Variation and Its Determinants in Chlamydomonas.Molecular biology and evolution · 2021Article
- Genetic and epigenetic Muller's ratchet as a mechanism of frailty and morbidity during aging: a demographic genetic model.Human genetics · 2020Article
- Inferring the distribution of fitness effects of spontaneous mutations in Chlamydomonas reinhardtii.PLoS biology · 2019Article
- Induced mutations alter patterns of quantitative variation, phenotypic integration, and plasticity to elevated COJournal of plant research · 2019Article
- Do slower movers have lower reproductive success and higher mutation load?Evolution letters · 2018Article
- Hierarchical Assessment of Mutation Properties inG3 (Bethesda, Md.) · 2018Article
- The genome-wide rate and spectrum of spontaneous mutations differ between haploid and diploid yeast.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
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Abstract
Although all genetic variation ultimately stems from mutations, their properties are difficult to study directly. Here, we used multiple mutation accumulation (MA) lines derived from five genetic backgrounds of the green algae Chlamydomonas reinhardtii that have been previously subjected to whole genome sequencing to investigate the relationship between the number of spontaneous mutations and change in fitness from a nonevolved ancestor. MA lines were on average less fit than their ancestors and we detected a significantly negative correlation between the change in fitness and the total number of accumulated mutations in the genome. Likewise, the number of mutations located within coding regions significantly and negatively impacted MA line fitness. We used the fitness data to parameterize a maximum likelihood model to estimate discrete categories of mutational effects, and found that models containing one to two mutational effect categories (one neutral and one deleterious category) fitted the data best. However, the best-fitting mutational effects models were highly dependent on the genetic background of the ancestral strain.
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