ArticleClinical pediatrics2018
Folic Acid in Pregnancy and Childhood Asthma: A US Cohort.
Article in Clinical pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 5 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Pooled it
- Dietary factors during pregnancy and atopic outcomes in childhood: A systematic review from the European Academy of Allergy and Clinical Immunology.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2020Pooled it
- Effect of Folic Acid Intake on Infant and Child Allergic Diseases: Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2020Pooled it
- Association of maternal folate intake during pregnancy with infant asthma risk.Scientific reports · 2019Pooled it
- Effect of Adherence to Mediterranean Diet during Pregnancy on Children's Health: A Systematic Review.Nutrients · 2019Pooled it
- Diet during Pregnancy and Allergy Onset in the Childhood: A Systematic Literature Review and Meta-Analysis.International journal of preventive medicine · 2026Review
- Biological, dietetic and pharmacological properties of vitamin BNPJ science of food · 2025Review
- First trimester prenatal metal mixtures, vitamins, and hypertensive disorders of pregnancy in the project viva cohort.Environment international · 2024Article
- The Early Appearance of Asthma and Its Relationship with Gut Microbiota: A Narrative Review.Microorganisms · 2024Review
- Uncovering the Hidden Dangers and Molecular Mechanisms of Excess Folate: A Narrative Review.Nutrients · 2023Review
- Scientific opinion on the tolerable upper intake level for folate.EFSA journal. European Food Safety Authority · 2023Article
- Mixtures of Metals and Micronutrients in Early Pregnancy and Cognition in Early and Mid-Childhood: Findings from the Project Viva Cohort.Environmental health perspectives · 2023Article
- Periconceptional folic acid supplementation and child asthma: aThe journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2022Article
- Periconceptional folic acid supplementation is a risk factor for childhood asthma: a case-control study.BMC pregnancy and childbirth · 2022Article
- S3 guideline Allergy Prevention.Allergologie select · 2022Article
- Maternal folic acid and multivitamin supplementation: International clinical evidence with considerations for the prevention of folate-sensitive birth defects.Preventive medicine reports · 2021Review
- Periconceptional folic acid supplementation and risk of parent-reported asthma in children at 4-6 years of age.ERJ open research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
Prenatal folic acid exposure has been linked to higher risk of childhood asthma in countries that do not fortify the food supply with folic acid. This study seeks to examine this association in the United States, where the food supply is generally fortified with folic acid. Participants were 1279 mother-child pairs from Project Viva, an ongoing prospective birth cohort, with folic acid intake in pregnancy assessed through validated food frequency questionnaires. The primary outcome was physician-diagnosed asthma at mid-childhood. In an unadjusted logistic regression model, higher folic acid intake was associated with lower odds of asthma in mid-childhood (odds ratio [OR] 0.48; 95% CI 0.31-0.76). However, in the adjusted analysis this association was attenuated (adjusted OR [aOR] 0.80; 95% CI 0.49-1.33). Our results suggest that in the United States, where there is generalized folic acid fortification of food, maternal folic acid intake during pregnancy is not associated with asthma development in offspring.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.