Observational studyJournal of gastroenterology2018
Pouch functional outcomes after restorative proctocolectomy with ileal-pouch reconstruction in patients with ulcerative colitis: Japanese multi-center nationwide cohort study.
Observational study in Journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Prevalence of 'pouch failure' of the ileoanal pouch in ulcerative colitis: a systematic review and meta-analysis.International journal of colorectal disease · 2022Pooled it
- Risk factors for fistulizing disease of the pouch after ileal pouch-Anal anastomosis for ulcerative colitis.Surgery today · 2026Article
- Article
- One-year stoma-free survival of ileoanal pouches for UC in European centers: The MIRACLE project.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2025Article
- Comparative analysis of robotic, laparoscopic, and open ileal pouch-anal anastomosis outcomes: retrospective cohort study.BJS open · 2025Article
- Prevalence and predictability of the Chicago Classification of Pouchitis in ulcerative colitis: a multicenter study in Japan.Journal of gastroenterology · 2025Article
- Crohn's-like Ileal Pouch Illness and Ileal Pouch Salvage Strategies.Clinics in colon and rectal surgery · 2025Review
- Feasibility and usefulness of the elongation of ileocolic pedicle with extended ileal resection on secure anastomosis after laparoscopic restorative proctocolectomy: a retrospective observational study.Techniques in coloproctology · 2025Observational
- 2-Stage and 3-stage restorative proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis show comparable short- and long-term outcomes.Scientific reports · 2024Article
- Creation of an institutional preoperative checklist to support clinical risk assessment in patients with ulcerative colitis (UC) considering ileoanal pouch surgery.Frontline gastroenterology · 2024Article
- Curable leakage in stapled IPAA has little effect on the long-term pouch function.International journal of colorectal disease · 2023Article
- A case of intestinal malrotation apparent after laparoscopically total proctocolectomy followed by ileal-pouch-anal anastomosis for ulcerative colitis.Asian journal of endoscopic surgery · 2023Article
- Pelvic Pouch Failure: Treatment Options.Clinics in colon and rectal surgery · 2022Review
- Postoperative complications, bowel function, and prognosis in restorative proctocolectomy for ulcerative colitis-a single-center observational study of 320 patients.International journal of colorectal disease · 2022Observational
- Article
- Sacral nerve stimulation in patients with ileal pouch-anal anastomosis.International journal of colorectal disease · 2021Article
- Ileal Pouch-anal Anastomosis Complications and Pouch Failure: A systematic review and meta-analysis.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2021Article
- Gastroduodenal Ulcerative Colitis in Association with Ulcerative Pancolitis.Case reports in gastrointestinal medicine · 2021Article
- Surgical results and quality of life of patients submitted to restorative proctocolectomy and ileal pouch-anal anastomosis.Revista do Colegio Brasileiro de Cirurgioes · 2021Article
- Clinical Results of One-stage Restorative Proctocolectomy with J-pouch Anal Anastomosis in 300 Ulcerative Colitis Patients.Journal of the anus, rectum and colon · 2020Article
Corrections and comments
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Authors and funding
23 authors at 14 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough several complications capable of causing pouch failure may develop after restorative proctocolectomy (RPC) for ulcerative colitis (UC), the incidences and causes are conflicting and vary according to country, race and institution. To avoid pouch failure, this study aimed to evaluate the rate of pouch failure and its risk factors in UC patients over the past decade via a nationwide cohort study.
methodsWe conducted a retrospective, observational, multicenter study that included 13 institutions in Japan. Patients who underwent RPC between January 2005 and December 2014 were included. The characteristics and backgrounds of the patients before and during surgery and their postoperative courses and complications were reviewed.
resultsA total of 2376 patients were evaluated over 6.7 ± 3.5 years of follow-up. Twenty-seven non-functional pouches were observed, and the functional pouch rate was 98.9% after RPC. Anastomotic leakage (odds ratio, 9.1) was selected as a risk factor for a non-functional pouch. The cumulative pouch failure rate was 4.2%/10 years. A change in diagnosis to Crohn's disease/indeterminate colitis (hazard ratio, 13.2) was identified as an independent risk factor for pouch failure.
conclusionThe significant risk factor for a non-functional pouch was anastomotic leakage. The optimal staged surgical procedure should be selected according to a patient's condition to avoid anastomotic failure during RPC. Changes in diagnosis after RPC confer a substantial risk of pouch failure. Additional cohort studies are needed to obtain an understanding of the long-standing clinical course of and proper treatment for pouch failure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.