ArticleJournal of dental anesthesia and pain medicine2016
Remifentanil induces autophagy and prevents hydrogen peroxide-induced apoptosis in Cos-7 cells.
Article in Journal of dental anesthesia and pain medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Resistance of HEK-293 and COS-7 cell lines to oxidative stress as a model of metabolic response.Acta biochimica Polonica · 2025Article
- Remifentanil attenuates sepsis-induced intestinal injury by inducing autophagy.Bioengineered · 2021Article
- Remifentanil ameliorates lung injury in neonate rats with acute respiratory distress by down-regulating TIMP1 expression.American journal of translational research · 2020Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study investigated the effect of remifentanil pretreatment on Cos-7 cells exposed to oxidative stress, and the influence of remifentanil on intracellular autophagy and apoptotic cell death.
methodsCells were divided into 4 groups: (1) Control: non-pretreated cells were incubated in normoxia (5% CO
resultsRemifentanil pretreatment increased the viability of Cos-7 cells exposed to oxidative stress. Hoechst staining and FACS analysis revealed that oxidative stress-dependent apoptosis was suppressed by the pretreatment. Additionally, fluorescence microscopy showed that remifentanil pretreatment led to autophagy-induction in Cos-7 cells, and the expression of autophagy-related proteins was increased in the RPC+H
conclusionsThe study showed that remifentanil pretreatment stimulated autophagy and increased viability in an oxidative stress model of Cos-7 cells. Therefore, we suggest that apoptosis was activated upon oxidative stress, and remifentanil preconditioning increased the survival rate of the cells by activating autophagy.
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