Evidence map›Paper›PMID 28884134›Full record

ArticleJournal of immunology research2017

Intracellular pH Regulates TRAIL-Induced Apoptosis and Necroptosis in Endothelial Cells.

Zhu-Xu Zhang, Ingrid Gan, Alexander Pavlosky, Xuyan Huang, Benjamin Fuhrmann, Anthony M Jevnikar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Zhu-Xu ZhangMatthew Mailing Centre for Translational Transplantation Studies, London Health Sciences Centre, London, ON, Canada.ORCID 0000-0002-8335-3738
Ingrid GanMatthew Mailing Centre for Translational Transplantation Studies, London Health Sciences Centre, London, ON, Canada.
Alexander PavloskyMatthew Mailing Centre for Translational Transplantation Studies, London Health Sciences Centre, London, ON, Canada.
Xuyan HuangMatthew Mailing Centre for Translational Transplantation Studies, London Health Sciences Centre, London, ON, Canada.
Benjamin FuhrmannMatthew Mailing Centre for Translational Transplantation Studies, London Health Sciences Centre, London, ON, Canada.
Anthony M JevnikarMatthew Mailing Centre for Translational Transplantation Studies, London Health Sciences Centre, London, ON, Canada.ORCID 0000-0002-3374-8758
Western University · CALondon Health Sciences Centre · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During ischemia or inflammation of organs, intracellular pH can decrease if acid production exceeds buffering capacity. Thus, the microenvironment can expose parenchymal cells to a reduced extracellular pH which can alter pH-dependent intracellular functions. We have previously shown that while silencing caspase-8 in an

Indexed as

ApoptosisNecrosisAnimalsCaspase 8Caspase InhibitorsCells, CulturedCytoplasmEndothelial CellsHydrogen-Ion ConcentrationInflammationMiceProtein KinasesReal-Time Polymerase Chain ReactionReceptor-Interacting Protein Serine-Threonine KinasesTNF-Related Apoptosis-Inducing LigandCaspase 8Caspase InhibitorsMLKL protein, mouseProtein KinasesReceptor-Interacting Protein Serine-Threonine KinasesRipk1 protein, mouseTNF-Related Apoptosis-Inducing Ligand

Identifiers

PMID28884134
PMCPMC5572609
OpenAlexW2744121986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.