Evidence map›Paper›PMID 28884086›Full record

ArticleAvicenna journal of phytomedicine

Anti-nociceptive and anti-inflammatory effects of the methanolic extract of

Bhesh Raj Sharma, Chul Min Park, Jong Won Choi, Dong Young Rhyu

Open access · greenAbstract read
In one paragraph

Article in Avicenna journal of phytomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Phenolic-Compound-RichNutrients · 2022
    Article
  4. Plants (Basel, Switzerland) · 2022
    Review
  5. Anti-Nociceptive and Anti-Inflammatory Activity ofJournal of inflammation research · 2020
    Article
  6. Journal of pharmacopuncture · 2019
    Review
  7. Evaluation on Analgesic and Anti-Inflammatory Activities of Total Flavonoids fromEvidence-based complementary and alternative medicine : eCAM · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Bhesh Raj SharmaDepartment of Oriental Medicine Resources Mokpo National University, Muan-gun, Jeonnam 58554, Republic of Korea.
Chul Min ParkDepartment of Oriental Medicine Resources Mokpo National University, Muan-gun, Jeonnam 58554, Republic of Korea.
Jong Won ChoiCollege of Pharmacy, Kyungsung University, Busan 48434, Republic of Korea.
Dong Young RhyuDepartment of Oriental Medicine Resources Mokpo National University, Muan-gun, Jeonnam 58554, Republic of Korea.
Mokpo National University · KRKyungsung University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveMATERIALS AND

methodsThe anti-nociceptive effect was measured by hot plate, acetic acid-induced writhing, and tail flick assays in mice and rats. Moreover, the anti-inflammatory effect was measured by vascular permeability and carrageenan and serotonin-induced paw edema tests in rats. Furthermore, anti-inflammatory effect was also measured using macrophage-like LPS-induced RAW 264.7 cells.

resultsOHS extract inhibited acetic acid-induced writhing (p<0.0001), and delayed the reaction time of mice to the hot plate-induced thermal stimulation (p<0.0001) and tail flick tests (p<0.05). OHS extract attenuated the carrageenan and serotonin-induced paw edema in rats (p<0.001). Similarly, OHS extract significantly decreased Evans blue concentration in acetic acid induced vascular permeability test (p<0.0001), revealing its strong anti-inflammatory effect. Finally, among four different fractions of OHS extract,

conclusionOur results suggest that the methanolic extract of

Indexed as

Anti-inflammatoryAnti-nociceptiveOpuntia humifusaRAW 264.7 cells

Identifiers

PMID28884086
PMCPMC5580874
OpenAlexW2585315912

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.