Evidence map›Paper›PMID 28884027›Full record

ArticleNeural plasticity2017

AAV-KLF7 Promotes Descending Propriospinal Neuron Axonal Plasticity after Spinal Cord Injury.

Wen-Yuan Li, Ying Wang, Feng-Guo Zhai, Ping Sun, Yong-Xia Cheng, Ling-Xiao Deng, Zhen-Yu Wang

Open access · goldAbstract read
In one paragraph

Article in Neural plasticity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

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  5. Molecular function of Krüppel-like factor 7 in biology.Acta biochimica et biophysica Sinica · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Wen-Yuan LiDepartment of Anatomy, Basic Medical College, China Medical University, Shenyang 110122, China.
Ying WangDepartment of Anatomy, Mudanjiang College of Medicine, Mudanjiang 157011, China.ORCID 0000-0002-5632-486X
Feng-Guo ZhaiDepartment of Pharmacy, Mudanjiang College of Medicine, Mudanjiang 157011, China.ORCID 0000-0003-0459-9658
Ping SunDepartment of Anatomy, Mudanjiang College of Medicine, Mudanjiang 157011, China.
Yong-Xia ChengDepartment of Pathology, Mudanjiang College of Medicine, Mudanjiang 157011, China.
Ling-Xiao DengSpinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-1293-8325
Zhen-Yu WangDepartment of Anatomy, Basic Medical College, China Medical University, Shenyang 110122, China.ORCID 0000-0001-9508-8911
Mudanjiang Normal University · CNChina Medical University · CNIndiana University School of Medicine

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DPSN axons mediate and maintain a variety of normal spinal functions. Unsurprisingly, DPSN tracts have been shown to mediate functional recovery following SCI. KLF7 could contribute to CST axon plasticity after spinal cord injury. In the present study, we assessed whether KLF7 could effectively promote DPSN axon regeneration and synapse formation following SCI. An AAV-KLF7 construct was used to overexpress KLF7.

Indexed as

AnimalsAxonsKruppel-Like Transcription FactorsMaleMiceMice, Inbred C57BLNerve RegenerationNeuronal PlasticityNeuronsRatsRecovery of FunctionSpinal Cord InjuriesSynapsesKlf7 protein, mouseKruppel-Like Transcription Factors

Identifiers

PMID28884027
PMCPMC5572611
OpenAlexW2742943279

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.