Evidence map›Paper›PMID 28884017›Full record

ArticleFuture science OA2017

Development and validation of an impedance biosensor for point-of-care detection of vascular cell adhesion molecule-1 toward lupus diagnostics.

Anjan Panneer Selvam, Andi Wangzhou, Michael Jacobs, Tianfu Wu, Chandra Mohan, Shalini Prasad

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Article in Future science OA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anjan Panneer SelvamDepartment of Bioengineering, University of Texas at Dallas, Richardson, TX 75080, USA.
Andi WangzhouDepartment of Bioengineering, University of Texas at Dallas, Richardson, TX 75080, USA.
Michael JacobsDepartment of Bioengineering, University of Texas at Dallas, Richardson, TX 75080, USA.
Tianfu WuDepartment of Internal Medicine, University of Texas at Southwestern Medical Center, Dallas, TX 75390, USA.
Chandra MohanDepartment of Internal Medicine, University of Texas at Southwestern Medical Center, Dallas, TX 75390, USA.
Shalini PrasadDepartment of Bioengineering, University of Texas at Dallas, Richardson, TX 75080, USA.

Funding

Foreboding Lupus Nephritis in Minority WomanR01DK081872 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI MOHAN, CHANDRA · 2009 to 2013
$2.4M
NIDDK NIH HHS R01 DK081872
6 · The paper itself

Abstract

aimSystemic lupus erythematosus is an autoimmune disease that requires chronic monitoring. In this study, we demonstrate a proof-of-concept study of a highly attractive noninvasive strategy for monitoring systemic lupus erythematosus through biomarker quantification.

resultsThis sensor technology requires 50 μl of urine to detect and quantify vascular cell adhesion molecule-1 in 15 min. The sensor used nonfaradaic detection to demonstrate performance with and without detection antibody. Binding of immunoassay and target biomarkers were quantified with an impedance electrical immunoassay and correlated with an equivalent circuit.

conclusionThe novel sensor technology demonstrates detection in the range of 8 fg/ml to 800 pg/ml and comparative analysis with ELISA platforms was performed for 12 patient urine samples.

Indexed as

impedance biosensorrapid urine screening testVCAM-1

Identifiers

PMID28884017
PMCPMC5583674

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.