ArticleFuture science OA2017
Identifying relationships between unrelated pharmaceutical target proteins on the basis of shared active compounds.
Article in Future science OA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Moving targets in drug discovery.Scientific reports · 2020Article
- Data structures for computational compound promiscuity analysis and exemplary applications to inhibitors of the human kinome.Journal of computer-aided molecular design · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimComputational exploration of small-molecule-based relationships between target proteins from different families. MATERIALS &
methodsTarget annotations of drugs and other bioactive compounds were systematically analyzed on the basis of high-confidence activity data.
resultsA total of 286 novel chemical links were established between distantly related or unrelated target proteins. These relationships involved a total of 1859 bioactive compounds including 147 drugs and 141 targets.
conclusionComputational analysis of large amounts of compounds and activity data has revealed unexpected relationships between diverse target proteins on the basis of compounds they share. These relationships are relevant for drug discovery efforts. Target pairs that we have identified and associated compound information are made freely available.
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