ReviewTropical diseases, travel medicine and vaccines2016
Diarrheal disease and enteric infections in LMIC communities: how big is the problem?
Review in Tropical diseases, travel medicine and vaccines, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Antibiotics for acute watery or persistent with or without bloody diarrhoea in children: A systematic review and meta-analysis.Journal of global health · 2024Pooled it
- Assessing the Impact of Animal Husbandry and Capture on Anemia among Women and Children in Low- and Middle-Income Countries: A Systematic Review.Advances in nutrition (Bethesda, Md.) · 2019Pooled it
- Overweight and obesity epidemic in Ghana-a systematic review and meta-analysis.BMC public health · 2016Pooled it
- Determinants of post-discharge stunting among diarrhoeal children aged 2-23 months in Bangladesh: findings from Antibiotics for Children with Severe Diarrhea (ABCD) trial.Journal of global health · 2025Trial
- Defining a target product profile for antimicrobials to treat severe paediatric bacterial enteric infections in low- and medium-income countries, caused byJAC-antimicrobial resistance · 2026Review
- Videography of pathways for enteric pathogen exposure among children in urban informal settlements in Fiji and Indonesia.BMC public health · 2026Article
- Parents' expectations for the management of pediatric diarrhea in the clinical setting: perspectives of parents and physicians in Bangladesh.Journal of tropical pediatrics · 2025Article
- Environmental Exposures Associated with Enteropathogen Infection in Six-Month-Old Children Enrolled in the ECoMiD Cohort along a Rural-Urban Gradient in Northern Ecuador†.Environmental science & technology · 2025Article
- Prevalence and factors associated with laboratory-confirmed cases of select enteric infections in three Ethiopian communities, 2018-2022.PLOS global public health · 2025Article
- Assessment of community readiness to address malnutrition in rural southwest Guatemala.Public health challenges · 2024Article
- Magnitude of enteric pathogens associated with diarrhea and antibiotic resistance of enteric bacterial pathogens isolated among children under 5 years of age in Bule Hora town, West Guji, Ethiopia.Frontiers in public health · 2024Article
- Network analysis of patterns and relevance of enteric pathogen co-infections among infants in a diarrhea-endemic setting.PLoS computational biology · 2023Article
- Local accessory gene sharing among EgyptianMicrobial genomics · 2022Article
- Determinants of multimorbidity of infectious diseases among under-five children in Bangladesh: role of community context.BMC pediatrics · 2022Article
- Exploring behavioural factors affecting nutritional supplement use among children in Honduras.Public health nutrition · 2022Article
- Growth faltering regardless of chronic diarrhea is associated with mucosal immune dysfunction and microbial dysbiosis in the gut lumen.Mucosal immunology · 2021Article
- The Gut Microbiota: A Promising Target in the Relation between Complementary Feeding and Child Undernutrition.Advances in nutrition (Bethesda, Md.) · 2021Review
- COVID-19 Crisis Creates Opportunity towards Global Monitoring & Surveillance.Pathogens (Basel, Switzerland) · 2021Review
- Regulation of Enteric Infection and Immunity by Dietary Proanthocyanidins.Frontiers in immunology · 2021Review
- High-throughput sequencing reveals genetic determinants associated with antibiotic resistance in Campylobacter spp. from farm-to-fork.PloS one · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies of enteric diseases have historically focused on observations of clinical diarrhea as a cause of mortality and morbidity. Emerging evidence suggests that diarrhea dramatically underestimates both exposure to enteropathogens and the long-term consequences arising from infection. High burden of pathogens in the gut, even in the absence of diarrhea, is common in infants in low and middle income countries. Continual challenge by pathogens, in conjunction with an inadequate diet stimulates an inflammatory disease that alters the structure of the gut, metabolic and immunological pathways and changes the microbiome. Both diarrhea and enteropathogen infection have been associated with reduced growth, reduced cognitive development, and reduced vaccine efficacy suggesting that the burden of diarrheal disease is dramatically underestimated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.