Evidence map›Paper›PMID 28883858›Full record

ArticleArchives of medical science : AMS2017

Association between low thyroid-stimulating hormone, posterior cortical atrophy and nitro-oxidative stress in elderly patients with cognitive dysfunction.

Adriana E Bulboacă, Sorana D Bolboacă, Angelo C Bulboacă, Călin I Prodan

Open access · goldAbstract read
In one paragraph

Article in Archives of medical science : AMS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Liposomal Curcumin Enhances the Effect of Naproxen in a Rat Model of Migraine.Medical science monitor : international medical journal of experimental and clinical research · 2019
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Adriana E BulboacăDepartment of Pathophysiology, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Sorana D BolboacăDepartment of Medical Informatics and Biostatistics, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Angelo C BulboacăDepartment of Neurology, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Călin I ProdanDepartment of Neurology, The University of Oklahoma Health Sciences Center & VA Medical Center, Oklahoma City, OK, USA.
Iuliu Hațieganu University of Medicine and Pharmacy · ROUniversity of Oklahoma Health Sciences Center · US

Funding

Stroke and Coated-Platelets - A Translational Research InitiativeI01CX000340 · VA · OKLAHOMA CITY VA MEDICAL CENTER · PI PRODAN, CALIN IOAN · 2011 to 2025
–
CSRD VA I01 CX000340
6 · The paper itself

Abstract

introductionCortical atrophy is known to be a valuable sign of cognitive decline. The purpose of this study was to assess the association between low thyroid-stimulating hormone (TSH), posterior cortical atrophy (Koedam score - KS) and nitro-oxidative stress in elderly patients. MATERIAL AND

methodsA study (SG) and a control group (CG), each subdivided by gender, were investigated. Subjects older than 59 years with low serum TSH level and with mild cognitive impairment were included in the SG. The CG was formed by subjects free of significant cortical atrophy and free or thyroid dysfunction. Demographic and clinical characteristics of the patients (Mini Mental State Examination, MMSE), Koedam score on cranial magnetic resonance imaging, and blood parameters (TSH, FT4, and nitric oxide - NOx) were assessed.

resultsSubjects in the study group had fewer years of education above the 8th grade compared with the control group (

conclusionsOur study revealed an association between subclinical thyroid hypofunction, nitro-oxidative stress, and posterior cortical atrophy as an early stage of global atrophy.

Indexed as

cognitive dysfunctioncortical atrophyoxidative stressthyroid

Identifiers

PMID28883858
PMCPMC5575209
OpenAlexW2475924140

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.