ArticleArchives of medical science : AMS2017
Postmenopausal cognitive changes and androgen levels in the context of apolipoprotein E polymorphism.
Article in Archives of medical science : AMS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Intervention Role of APOE in CNS Diseases: APOE Actions and APOE Neurogenesis Capability.Molecular neurobiology · 2025Review
- Associations between blood sex hormones, cognitive decline and incident dementia in community-dwelling older Australian women: a prospective cohort study.Climacteric : the journal of the International Menopause Society · 2025Article
- Sex hormones, SHBG and cognitive performance among older Australian women: an observational study.Climacteric : the journal of the International Menopause Society · 2023Observational
- The challenges of androgen insensitivity syndrome.Archives of medical science : AMS · 2022Article
- Oestrogen receptor α gene polymorphisms, insomnia, and cognitive functions in perimenopausal and postmenopausal women in non-manual employment.Archives of medical science : AMS · 2022Article
- Associations of Sleep Quality, Anxiety, and Depression with Cognitive and Executive Functions among Community-Dwelling Women Aged ≥ 65 Years: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2021Article
- Effect of interactions betweenArchives of medical science : AMS · 2021Article
- Impact of adrenal hormones, reproductive aging, and major depression on memory circuitry decline in early midlife.Brain research · 2019Article
- Improvement in cognitive impairment following the successful treatment of endogenous Cushing's syndrome-a case report and literature review.BMC endocrine disorders · 2019Review
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe focus of this study was to assess cognitive functions in relation to androgens and specifically testosterone and dehydroepiandrosterone in postmenopausal women as well as the correlation between cognitive functions and these two androgens according to polymorphism of the apolipoprotein E gene (APOE). MATERIAL AND
methodsA group of 402 women was recruited to the study (minimum 2 years after the last menstruation, follicle-stimulating hormone (FSH) more than 30 U/ml and no dementia signs on Montreal Cognitive Assessment). The computerized battery of the Central Nervous System Vital Signs test was used to diagnose cognitive functions. APOE genotyping was performed by multiplex polymerase chain reaction (PCR). Testosterone (TTE) and dehydroepiandrosterone (DHEA) in the blood serum were assessed for further statistical correlations analysis.
resultsIn the group of postmenopausal women, higher testosterone concentration was associated with lower scores for Neurocognition Index (NCI) (
conclusionsHormonal balance variations after menopause may influence brain processes concerned with cognition, especially memory and psychomotor speed. The observed effects may be related to androgens' influence on higher cortical functions in the changed hormonal dynamics of the postmenopausal period.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.