ArticleArchives of medical science : AMS2017
Interleukin-21 gene polymorphism rs2221903 is associated with disease activity in patients with rheumatoid arthritis.
Article in Archives of medical science : AMS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Associations between interleukin-37 gene polymorphisms and susceptibility and clinical outcomes of rheumatoid arthritis: a meta-analysis and systematic review.BMC rheumatology · 2026Pooled it
- Association between interleukin-21 gene rs6822844 polymorphism and rheumatoid arthritis susceptibility.Bioscience reports · 2019Pooled it
- Association of genetic polymorphisms on methotrexate toxicity in patients with rheumatoid arthritis.Archives of medical science : AMS · 2026Article
- Impact of interaction between IL-21 gene variants and smoking status on susceptibility to rheumatoid arthritis.BMC medical genomics · 2025Article
- Pro-inflammatory cytokine IL-21 correlates with the reactive oxygen species and 25-hydroxy vitamin D in rheumatoid arthritis patients.Immunity, inflammation and disease · 2024Article
- Association of RIPK1 and RIPK2 Gene Polymorphisms with Rheumatoid Arthritis in a Chinese Han Population.The application of clinical genetics · 2024Article
- IL-21 (rs2055979 and rs2221903)/Genes · 2023Article
- The association between interleukin-1β gene polymorphisms and the risk of breast cancer: a systematic review and meta-analysis.Archives of medical science : AMS · 2022Review
- Association betweenWorld journal of gastrointestinal oncology · 2020Article
- IL-21 gene rs6822844 polymorphism and rheumatoid arthritis susceptibility.Bioscience reports · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionInterleukin-21 (IL-21) is a cytokine which plays a significant role in the pathogenesis and disease activity of rheumatoid arthritis (RA). Genetic polymorphisms in the MATERIAL AND
methodsWe examined 422 patients with RA and 338 healthy controls. Single nucleotide polymorphisms (SNPs) within the
resultsThere were no statistically significant differences in the distribution of studied genotypes and alleles between RA patients and the control group. To examine whether IL-21 polymorphisms affect disease activity in RA patients, we compared the distribution of IL-21 genotypes between patients with DAS28 ≤ 2.5 (patients with remission of disease symptoms) and patients with DAS28 > 2.5 (patients with active RA). Among patients with DAS28 > 2.5, increased prevalence of rs2221903 CT and CC genotypes was observed (OR = 1.54; 95% CI: 1.04-2.28;
conclusionsThe results of this study suggest that IL-21 and IL-21R gene polymorphisms are not risk loci for RA susceptibility, whereas the
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