ArticleArchives of medical science : AMS2017
The impact of hyperglycemia and hyperlipidemia on plasma P-selectin and platelet markers after ischemic stroke.
Article in Archives of medical science : AMS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Ischemic stroke associated with COVID-19: a systematic review and meta-analysis.Journal of neurology · 2022Pooled it
- Pooled it
- Platelet Activation and Platelet-Leukocyte Aggregates in Type I Diabetes Mellitus.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2018Trial
- The Role of Extracellular Vesicles in Transient Ischaemic Attacks and Ischaemic Stroke: A Systematic Review.Journal of extracellular biology · 2026Review
- Prediabetes and stroke risk in U.S. adults: a machine learning-based analysis with causal mediation insights.Diabetology & metabolic syndrome · 2026Article
- A prospective cohort study on prognostic implications of serum platelet derived microparticles levels in acute cerebral infarction.Scientific reports · 2025Article
- Potential Predictive Value of Platelet Distribution Width for Functional Outcome After Ischemic Stroke.Molecular neurobiology · 2025Article
- Antiplatelet Effects of a Combination of Sappan Wood (Advances in pharmacological and pharmaceutical sciences · 2024Article
- High-Fat Diet Enhances Platelet Activation and Is Associated with Proprotein Convertase Subtilisin Kexin 9: An Animal Study.Nutrients · 2023Article
- Article
- Oxidised Low-Density Lipoprotein-Induced Platelet Hyperactivity-Receptors and Signalling Mechanisms.International journal of molecular sciences · 2022Review
- Non-Lipid Effects of PCSK9 Monoclonal Antibodies on Vessel Wall.Journal of clinical medicine · 2022Review
- Circulating Extracellular Vesicles Are Strongly Associated With Cardiovascular Risk Markers.Frontiers in cardiovascular medicine · 2022Article
- Risk of acute atherosclerotic cardiovascular disease in patients with acute and chronic pancreatitis.Scientific reports · 2021Article
- Association of laboratory parameters and genetic polymorphisms with ischemic stroke in Chinese Han population.Experimental and therapeutic medicine · 2021Article
- Altered Gene Expression Profiles in the Lungs of Streptozotocin-induced Diabetic Mice.Development & reproduction · 2020Article
- Putative functional non-coding polymorphisms in SELP significantly modulate sP-selectin levels, arterial stiffness and type 2 diabetes mellitus susceptibility.BMC endocrine disorders · 2020Article
- Article
- The impact of the AHSG genetic polymorphism on the risk of ischemic stroke: a case-control study.International journal of clinical and experimental pathology · 2018Article
- Hyperlipidemia in Stroke Pathobiology and Therapy: Insights and Perspectives.Frontiers in physiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPlatelet activation plays a key role in the pathogenesis of ischemic cerebrovascular diseases. Thus, it is very important to identify novel pharmacological targets for platelet inhibition to improve ischemic stroke treatment. The aim of the study was to assess the relationship between metabolic disorders and platelet activity markers in patients with acute ischemic stroke. MATERIAL AND
methodsNinety-four patients with acute ischemic stroke were divided into four groups with: normolipidemia and normoglycemia (NL/NG),
resultsWe observed a significant influence of hyperlipidemia and hyperglycemia on sP-selectin concentration. A strong correlation between higher sP-selectin concentration and enhanced LDL (
conclusionsHyperlipidemia and hyperglycemia exert an equal stimulatory effect on tested platelet markers but with no synergistic action in stroke patients with both of the metabolic comorbidities. sP-selectin concentration in stroke patients best reflects the impact of hyperglycemia and hyperlipidemia on vascular lesions and platelet activation.
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Registered trials
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