Evidence map›Paper›PMID 28883727›Full record

ArticleInternational journal of nanomedicine2017

Vaccination with poly(D,L-lactide-co-glycolide) nanoparticles loaded with soluble

Maritsa Margaroni, Maria Agallou, Evita Athanasiou, Olga Kammona, Costas Kiparissides, Catherine Gaitanaki, Evdokia Karagouni

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maritsa MargaroniLaboratory of Cellular Immunology, Department of Microbiology, Hellenic Pasteur Institute.
Maria AgallouLaboratory of Cellular Immunology, Department of Microbiology, Hellenic Pasteur Institute.
Evita AthanasiouLaboratory of Cellular Immunology, Department of Microbiology, Hellenic Pasteur Institute.
Olga KammonaChemical Process & Energy Resources Institute, Centre for Research and Technology Hellas.
Costas KiparissidesChemical Process & Energy Resources Institute, Centre for Research and Technology Hellas.
Catherine GaitanakiDepartment of Animal and Human Physiology, School of Biology, National and Kapodistrian University of Athens, Athens.
Evdokia KaragouniLaboratory of Cellular Immunology, Department of Microbiology, Hellenic Pasteur Institute.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Visceral leishmaniasis (VL) persists as a major public health problem, and since the existing chemotherapy is far from satisfactory, development of an effective vaccine emerges as the most appropriate strategy for confronting VL. The development of an effective vaccine relies on the selection of the appropriate antigen and also the right adjuvant and/or delivery vehicle. In the present study, the protective efficacy of poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs), which were surface-modified with a TNFα-mimicking eight-amino-acid peptide (p8) and further functionalized by encapsulating soluble

Indexed as

Adjuvants, ImmunologicAnimalsAntigens, ProtozoanCD8-Positive T-LymphocytesFemaleImmunity, CellularInterleukin-10Interleukin-4Lactic AcidLeishmania infantumLeishmaniasis VaccinesLeishmaniasis, VisceralLipid AMice, Inbred BALB CNanoparticlesPeptidesAdjuvants, ImmunologicAntigens, ProtozoanInterleukin-10Interleukin-4Lactic AcidLeishmaniasis VaccinesLipid Amonophosphoryl lipid APeptidesPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerTumor Necrosis Factor-alphacytokinesimmune responsenanovaccinesoluble Leishmania antigenT cellsvisceral leishmaniasis

Identifiers

PMID28883727
PMCPMC5574665

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.