ArticleScientific reports2017
Visualizing Micro-anatomical Structures of the Posterior Cornea with Micro-optical Coherence Tomography.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 56 citations in OpenAlex.
- Nanosensitive optical coherence tomography to monitor corneal burn and treatment response in vivo.Biomedical optics express · 2026Article
- Applied Anatomical and Morphological Characterization of the Ocular Surface of the African Spiny Mice: Acomys cahirinus.Investigative ophthalmology & visual science · 2026Article
- Clinical and economic impacts of optical coherence tomography prior to cataract surgery in a low-to-middle-income country.Frontiers in ophthalmology · 2026Article
- Enabling In Vivo Longitudinal Evaluation of Descemet's Membrane Thickness in Wild-type and FECD Mice Using Self-Referenced Optical Coherence Microscopy.Investigative ophthalmology & visual science · 2025Article
- In vivo, contactless, cellular resolution imaging of the human cornea with Powell lens based line field OCT.Scientific reports · 2024Article
- Non-invasiveBiomedical optics express · 2023Article
- Correcting spatial-spectral crosstalk and chromatic aberrations in broadband line-scan spectral-domain OCT images.Biomedical optics express · 2023Article
- Powell lens-based line-field spectral domain optical coherence tomography system for cellular resolution imaging of biological tissue.Biomedical optics express · 2023Article
- Ex vivo demonstration of canine corneal pre-Descemet's anatomy using pneumodissection as for the big bubble technique for deep anterior lamellar keratoplasty.Scientific reports · 2023Article
- Recent advances in optical coherence tomography for anterior segment imaging in small animals and their clinical implications.The ocular surface · 2022Review
- Corneal imaging with blue-light optical coherence microscopy.Biomedical optics express · 2022Article
- Line-scanning SD-OCT forBiomedical optics express · 2022Article
- A unique pre-endothelial layer at the posterior peripheral cornea: ultrastructural study.Scientific reports · 2022Article
- Advances in Imaging of Subbasal Corneal Nerves With Micro-Optical Coherence Tomography.Translational vision science & technology · 2021Article
- Micro-optical coherence tomography for high-resolution morphologic imaging of cellular and nerval corneal micro-structures.Biomedical optics express · 2020Article
- Article
- Imaging intracellular motion with dynamic micro-optical coherence tomography.Biomedical optics express · 2020Article
- Article
- Stromal Nerve Imaging and Tracking Using Micro-Optical Coherence Tomography.Translational vision science & technology · 2020Article
- Noninvasive and Noncontact Sequential Imaging of the Iridocorneal Angle and the Cornea of the Eye.Translational vision science & technology · 2020Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diagnosis of corneal disease and challenges in corneal transplantation require comprehensive understanding of corneal anatomy, particularly that of the posterior cornea. Micro-optical coherence tomography (µOCT) is a potentially suitable tool to meet this need, owing to its ultrahigh isotropic spatial resolution, high image acquisition rate and depth priority scanning mode. In this study, we explored the ability of µOCT to visualize micro-anatomical structures of the posterior cornea ex vivo and in vivo using small and large animals. µOCT clearly delineated cornea layers and revealed micro-anatomical structures, including not only polygonal endothelial cells, stellate keratocytes, collagen fibres and corneal nerve fibres but also new structures such as the dome-shaped basolateral side of endothelial cells and lattice structures at the interface between endothelium and Descemet's membrane. Based on these observations, a short post-harvest longitudinal study was conducted on rat cornea to test the feasibility of using µOCT to monitor the quality of endothelial cells. This study successfully reveals a series of morphological features and pathological changes in the posterior cornea at the cellular level in situ and in real time with µOCT. These findings enrich knowledge of corneal anatomy and suggest that µOCT may be a promising imaging tool in corneal transplantation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.