ArticleScientific reports2017
Running reorganizes the circuitry of one-week-old adult-born hippocampal neurons.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Mapping the effects of exercise on cognition and physical function: a scoping review of rodent studies.Frontiers in physiology · 2026Pooled it
- Exercise training promotes neurogenesis in the adult hippocampus with a particular focus on cell cycle regulation.Frontiers in sports and active living · 2026Review
- Early spinogenesis in postnatally-born hippocampal granule cells.Frontiers in neuroanatomy · 2026Article
- Swimming Training Prevents Stress-Induced Spatial Memory Impairment by Reducing Neurodegenerative Changes in Hippocampus.Biochemistry research international · 2025Article
- Reversal of high-fat diet-induced cognitive impairment and oxidative stress in the brain through Zingiber officinale supplementation.Metabolic brain disease · 2024Article
- Exercise training improves long-term memory in obese mice.Life metabolism · 2024Article
- Exercise Reshapes the Brain: Molecular, Cellular, and Structural Changes Associated with Cognitive Improvements.Molecular neurobiology · 2023Review
- Altered connectomes of adult-born granule cells following engraftment of GABAergic progenitors in the mouse hippocampus.Progress in neurobiology · 2023Article
- Article
- Mechanisms underlying the effect of voluntary running on adult hippocampal neurogenesis.Hippocampus · 2023Review
- Adult hippocampal neurogenesis in Alzheimer's disease: A roadmap to clinical relevance.Cell stem cell · 2023Review
- State of Knowledge on Molecular Adaptations to Exercise in Humans: Historical Perspectives and Future Directions.Comprehensive Physiology · 2022Article
- Basal Forebrain Impairment: Understanding the Mnemonic Function of the Septal Region Translates in Therapeutic Advances.Frontiers in neural circuits · 2022Review
- Hippocampal neurogenesis mediates sex-specific effects of social isolation and exercise on fear extinction in adolescence.Neurobiology of stress · 2021Article
- Exercise hormone irisin is a critical regulator of cognitive function.Nature metabolism · 2021Article
- A Runner's High for New Neurons? Potential Role for Endorphins in Exercise Effects on Adult Neurogenesis.Biomolecules · 2021Review
- Adult-born granule cell mossy fibers preferentially target parvalbumin-positive interneurons surrounded by perineuronal nets.Hippocampus · 2021Article
- A critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy.Nature communications · 2021Article
- Physical Exercise Modulates Brain Physiology Through a Network of Long- and Short-Range Cellular Interactions.Frontiers in molecular neuroscience · 2021Review
- Recruitment of parvalbumin and somatostatin interneuron inputs to adult born dentate granule neurons.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adult hippocampal neurogenesis is an important form of structural and functional plasticity in the mature mammalian brain. The existing consensus is that GABA regulates the initial integration of adult-born neurons, similar to neuronal development during embryogenesis. Surprisingly, virus-based anatomical tracing revealed that very young, one-week-old, new granule cells in male C57Bl/6 mice receive input not only from GABAergic interneurons, but also from multiple glutamatergic cell types, including mature dentate granule cells, area CA1-3 pyramidal cells and mossy cells. Consistently, patch-clamp recordings from retrovirally labeled new granule cells at 7-8 days post retroviral injection (dpi) show that these cells respond to NMDA application with tonic currents, and that both electrical and optogenetic stimulation can evoke NMDA-mediated synaptic responses. Furthermore, new dentate granule cell number, morphology and excitatory synaptic inputs at 7 dpi are modified by voluntary wheel running. Overall, glutamatergic and GABAergic innervation of newly born neurons in the adult hippocampus develops concurrently, and excitatory input is reorganized by exercise.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.