Evidence map›Paper›PMID 28883635›Full record

ArticleScientific reports2017

Tissue alkalosis in cold-ischemia time.

V Denninghoff, E H R Olivieri, C Fresno, A Uceda, L Mota, A P Suenaga, D M Carraro, V R Martins, A Avagnina, F A Soares and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

V DenninghoffDepartment of Pathology, A. C. Camargo Cancer Center, São Paulo, Brazil. vcdennin@yahoo.com.ar.
E H R OlivieriInternational Center for Research (CIPE), A. C. Camargo Cancer Center, São Paulo, Brazil.
C FresnoComputational Genomics Division, National Institute of Genomic Medicine (INMEGEN), México city, Mexico.
A UcedaDepartment of Pathology & Biobank, Center for Medical Education and Clinical Research "Norberto Quirno" (CEMIC), Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.
L MotaA. C. Camargo Biobank, A. C. Camargo Cancer Center, São Paulo, Brazil.
A P SuenagaA. C. Camargo Biobank, A. C. Camargo Cancer Center, São Paulo, Brazil.
D M CarraroInternational Center for Research (CIPE), A. C. Camargo Cancer Center, São Paulo, Brazil.
V R MartinsInternational Center for Research (CIPE), A. C. Camargo Cancer Center, São Paulo, Brazil.
A AvagninaDepartment of Pathology & Biobank, Center for Medical Education and Clinical Research "Norberto Quirno" (CEMIC), Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.
F A SoaresDepartment of Pathology, A. C. Camargo Cancer Center, São Paulo, Brazil.
A H J Fróes Marques CamposDepartment of Pathology, A. C. Camargo Cancer Center, São Paulo, Brazil. ahcampos@accamargo.org.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The control of pre-analytical-factors in human biospecimens collected for health research is currently required. Only two previous reports using post-mortem brain samples have tried to address the impact of cold-ischemia on tissue pH. Here we report pH variations according to time (third-order polynomial model) in mice for liver, kidney and lung samples. Tissue alkalosis in cold-ischemia time may be an underlying mechanism of gene expression changes. Therefore, tissue-pH regulation after organ removal may minimize biological stress in human tissue samples.

Indexed as

Cold TemperatureAlkalosisAnimalsFemaleHydrogen-Ion ConcentrationIschemiaKidneyLiverLungMaleMiceTime Factors

Identifiers

PMID28883635
PMCPMC5589730

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.