Evidence map›Paper›PMID 28883608›Full record

ArticleScientific reports2017

GYY4137, a Hydrogen Sulfide Donor Modulates miR194-Dependent Collagen Realignment in Diabetic Kidney.

A M Sashi Papu John, Sourav Kundu, Sathnur Pushpakumar, Maura Fordham, Gregory Weber, Manas Mukhopadhyay, Utpal Sen

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Recent Advances in Molecular Research on Hydrogen Sulfide (HInternational journal of molecular sciences · 2022
    Pooled it
  2. Review
  3. Article
  4. HHandbook of experimental pharmacology · 2026
    Review
  5. Protective Role of HDiabetes, metabolic syndrome and obesity : targets and therapy · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Mechanisms and Application of Gas-Based Anticancer Therapies.Pharmaceuticals (Basel, Switzerland) · 2023
    Review
  10. Diabetic Nephropathy and Gaseous Modulators.Antioxidants (Basel, Switzerland) · 2023
    Review
  11. Article
  12. Article
  13. Review
  14. Unmet needs in glaucoma therapy: The potential role of hydrogen sulfide and its delivery strategies.Journal of controlled release : official journal of the Controlled Release Society · 2022
    Review
  15. Hydrogen Sulfide Biology and Its Role in Cancer.Molecules (Basel, Switzerland) · 2022
    Review
  16. The Pathophysiology of HBiomolecules · 2022
    Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

A M Sashi Papu JohnDepartment of Physiology, University of Louisville, School of Medicine, Louisville, KY, 40202, United States.
Sourav KunduDepartment of Physiology, University of Louisville, School of Medicine, Louisville, KY, 40202, United States.
Sathnur PushpakumarDepartment of Physiology, University of Louisville, School of Medicine, Louisville, KY, 40202, United States.
Maura FordhamDepartment of Physiology, University of Louisville, School of Medicine, Louisville, KY, 40202, United States.
Gregory WeberDepartment of Physiology, University of Louisville, School of Medicine, Louisville, KY, 40202, United States.
Manas MukhopadhyayDepartment of Physiology, University of Louisville, School of Medicine, Louisville, KY, 40202, United States.
Utpal SenDepartment of Physiology, University of Louisville, School of Medicine, Louisville, KY, 40202, United States. u0sen001@louisville.edu.
University of Louisville · US

Funding

Hydrogen sulfide mechanism of renal hypertensionR01DK104653 · NIDDK · UNIVERSITY OF LOUISVILLE · PI SEN, UTPAL, TYAGI, SURESH C. · 2015 to 2018
$2.5M
Homocysteine & Angiotensin II in Renovascular RemodelingR01HL104103 · NHLBI · UNIVERSITY OF LOUISVILLE · PI SEN, UTPAL · 2011 to 2015
$1.8M
NHLBI NIH HHS R01 HL104103NIDDK NIH HHS R01 DK104653
6 · The paper itself

Abstract

The relationship between hydrogen sulfide (H

Indexed as

AnimalsCollagenDiabetic NephropathiesDisease Models, AnimalEndothelial CellsHydrogen SulfideMatrix MetalloproteinasesMiceMicroRNAsMorpholinesOrganothiophosphorus CompoundsPoly (ADP-Ribose) Polymerase-1Treatment OutcomeCollagenGYY 4137Hydrogen SulfideMatrix MetalloproteinasesMicroRNAsMIRN194 microRNA, mouseMorpholinesOrganothiophosphorus CompoundsParp1 protein, mousePoly (ADP-Ribose) Polymerase-1

Identifiers

PMID28883608
PMCPMC5589897
OpenAlexW2751958676

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.