Evidence map›Paper›PMID 28883544›Full record

ArticleScientific reports2017

Global fibroblast activation throughout the left ventricle but localized fibrosis after myocardial infarction.

Chandan K Nagaraju, Eef Dries, Natasa Popovic, Abhishek A Singh, Peter Haemers, H Llewelyn Roderick, Piet Claus, Karin R Sipido, Ronald B Driesen

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 84 citations in OpenAlex.

  1. Article
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  6. Total-body positron emission tomography: Investigating mechanisms in cardiovascular-kidney-metabolic syndrome.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2025
    Review
  7. Fibroblast Activation Protein Inhibitor (FAPI)-Based Theranostics.Pharmaceuticals (Basel, Switzerland) · 2025
    Review
  8. Article
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  10. Observational
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  16. Value of [European radiology · 2024
    Article
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Chandan K NagarajuExperimental Cardiology, Department of Cardiovascular Sciences, KU Leuven, Herestraat 49, Leuven, 3000, Belgium.
Eef DriesExperimental Cardiology, Department of Cardiovascular Sciences, KU Leuven, Herestraat 49, Leuven, 3000, Belgium.
Natasa PopovicCardiovascular Imaging and Dynamics, Department of Cardiovascular Sciences, KU Leuven, Herestraat 49, Leuven, 3000, Belgium.
Abhishek A SinghExperimental Cardiology, Department of Cardiovascular Sciences, KU Leuven, Herestraat 49, Leuven, 3000, Belgium.
Peter HaemersExperimental Cardiology, Department of Cardiovascular Sciences, KU Leuven, Herestraat 49, Leuven, 3000, Belgium.
H Llewelyn RoderickExperimental Cardiology, Department of Cardiovascular Sciences, KU Leuven, Herestraat 49, Leuven, 3000, Belgium.
Piet ClausCardiovascular Imaging and Dynamics, Department of Cardiovascular Sciences, KU Leuven, Herestraat 49, Leuven, 3000, Belgium.
Karin R SipidoExperimental Cardiology, Department of Cardiovascular Sciences, KU Leuven, Herestraat 49, Leuven, 3000, Belgium. karin.sipido@kuleuven.be.
Ronald B DriesenExperimental Cardiology, Department of Cardiovascular Sciences, KU Leuven, Herestraat 49, Leuven, 3000, Belgium.
KU Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fibroblast (Fb) differentiation and interstitial fibrosis contribute to cardiac remodeling and loss of function after myocardial infarction (MI). We investigated regional presence and regulation of fibrosis in a pig MI model. In vivo analysis of regional function and perfusion defined three regions: the scar, the myocardium adjacent to the scar (MI

Indexed as

Cell DifferentiationAnimalsCollagen Type IDisease Models, AnimalEndopeptidasesFibroblast Activation Protein AlphaFibroblastsFibrosisGelatinasesHeart VentriclesMembrane ProteinsMyocardial InfarctionProtein-Lysine 6-OxidaseProteoglycansSerine EndopeptidasesSignal TransductionCollagen Type IEndopeptidasesFibroblast Activation Protein AlphaGelatinasesMembrane ProteinsProtein-Lysine 6-OxidaseProteoglycansSerine EndopeptidasesTransforming Growth Factor beta1

Identifiers

PMID28883544
PMCPMC5589875
OpenAlexW2750655551

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.