Evidence map›Paper›PMID 28883515›Full record

ArticleScientific reports2017

Factor Xa Mediates Calcium Flux in Endothelial Cells and is Potentiated by Igg From Patients With Lupus and/or Antiphospholipid Syndrome.

Bahar Artim-Esen, Natalia Smoktunowicz, Thomas McDonnell, Vera M Ripoll, Charis Pericleous, Ian Mackie, Eifion Robinson, David Isenberg, Anisur Rahman, Yiannis Ioannou and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 2 countries.

Bahar Artim-EsenCenter for Rheumatology Research, Rayne Institute, University College London, London, UK. bahar.artimesen@istanbul.edu.tr.
Natalia SmoktunowiczCenter for Inflammation and Tissue Repair, Rayne Institute, University College London, London, UK.
Thomas McDonnellCenter for Rheumatology Research, Rayne Institute, University College London, London, UK.
Vera M RipollCenter for Rheumatology Research, Rayne Institute, University College London, London, UK.
Charis PericleousCenter for Rheumatology Research, Rayne Institute, University College London, London, UK.
Ian MackieHaemostasis Research Unit, Department of Haematology, University College London, London, UK.ORCID 0000-0002-7393-2365
Eifion RobinsonDepartment of Chemistry, Faculty of Maths and Physical Sciences, University College London, London, UK.
David IsenbergCenter for Rheumatology Research, Rayne Institute, University College London, London, UK.
Anisur RahmanCenter for Rheumatology Research, Rayne Institute, University College London, London, UK.
Yiannis IoannouCenter for Rheumatology Research, Rayne Institute, University College London, London, UK.
Rachel C ChambersCenter for Inflammation and Tissue Repair, Rayne Institute, University College London, London, UK.
Ian GilesCenter for Rheumatology Research, Rayne Institute, University College London, London, UK.
University College London · GB

Funding

Versus Arthritis 19423
6 · The paper itself

Abstract

Factor (F) Xa reactive IgG isolated from patients with antiphospholipid syndrome (APS) display higher avidity binding to FXa with greater coagulant effects compared to systemic lupus erythematosus (SLE) non APS IgG. FXa signalling via activation of protease-activated receptors (PAR) leads to increased intracellular calcium (Ca

Indexed as

Antiphospholipid SyndromeBiomarkersCalciumCase-Control StudiesEndothelial CellsFactor XaFemaleHumansHuman Umbilical Vein Endothelial CellsImmunoglobulin GIntracellular SpaceLupus Erythematosus, SystemicMalePlatelet Aggregation InhibitorsReceptor, PAR-2Signal TransductionBiomarkersCalciumFactor XaImmunoglobulin GPlatelet Aggregation InhibitorsReceptor, PAR-2

Identifiers

PMID28883515
PMCPMC5589732
OpenAlexW2750622869

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.