ArticleScientific reports2017
The circadian clock in immune cells controls the magnitude of Leishmania parasite infection.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed.
- Short- and Long-Term Chrono-Immune Consequences of Dim Light at Night Exposure in Male Mice at Different Life Stages.Clocks & sleep · 2026Article
- A Chrono-Metabolic Approach to Mental Health: Current Perspectives on Circadian Rhythms, Gut Microbiota, and Microbial Metabolites in Mood Disorders.Metabolites · 2026Review
- A temporal dialogue between the circadian clock and chronic inflammatory diseases.Disease models & mechanisms · 2026Review
- Time of day alters olfactory bulb immune state with ramifications for intranasal inflammatory challenge.Cell reports · 2026Article
- Circadian considerations in antimicrobials.European journal of clinical pharmacology · 2026Review
- Epigenetic landscape of Leishmania-host interactions.Epigenomics · 2025Review
- Time-of-day of infection: impact on liver stage malaria parasites in untreated and drug-treated hosts.Parasites & vectors · 2025Article
- Enigmatic Roles of Complement Anaphylatoxin Signaling in Health and Disease.Immune network · 2025Review
- The βScience advances · 2025Article
- The diverse roles of the circadian clock in cancer.Nature cancer · 2025Review
- Circadian metabolic adaptations to infections.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Time to start taking time seriously: how to investigate unexpected biological rhythms within infectious disease research.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Chronopharmacology of AAV gene therapy in mice.microPublication biology · 2025Article
- Review
- Disruption of the intestinal clock drives dysbiosis and impaired barrier function in colorectal cancer.Science advances · 2024Article
- Targeting the intestinal circadian clock by meal timing ameliorates gastrointestinal inflammation.Cellular & molecular immunology · 2024Article
- Non-Hereditary Obesity Type Networks and New Drug Targets: An In Silico Approach.International journal of molecular sciences · 2024Article
- Circadian Control of the Response of Macrophages to Plasmodium Spp.-Infected Red Blood Cells.ImmunoHorizons · 2024Article
- Time of day and circadian disruption influence host response and parasite growth in a mouse model of cerebral malaria.iScience · 2024Article
- Crosstalk between circadian clocks and pathogen niche.PLoS pathogens · 2024Review
11 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
Abstract
The intracellular parasite Leishmania uses neutrophils and macrophages as host cells upon infection. These immune cells harbour their own intrinsic circadian clocks, known to influence many aspects of their functions. Therefore, we tested whether the host circadian clocks regulate the magnitude of Leishmania major infection in mice. The extent of parasitic infection varied over 24 h in bone marrow-derived macrophages in vitro and in two different in vivo models, footpad and peritoneal cavity infection. In vivo this was paralleled by time of day-dependent neutrophil and macrophage infiltration to the infection site and rhythmic chemokine expression. Thus, rhythmic parasitic infection observed in vivo was likely initiated by the circadian expression of chemoattractants and the subsequent rhythmic infiltration of neutrophils and macrophages. Importantly, all rhythms were abolished in clock-deficient macrophages and when mice lacking the circadian clock in immune cells were infected. Therefore we demonstrated a critical role for the circadian clocks in immune cells in modulating the magnitude of Leishmania infection. To our knowledge this is the first report showing that the circadian clock controls infection by protozoan parasites in mammals. Understanding the timed regulation of host-parasite interactions will allow developing better prophylactic and therapeutic strategies to fight off vector-borne diseases.
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