ArticleScientific reports2017
Channel Formation and Membrane Deformation via Sterol-Aided Polymorphism of Amphidinol 3.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Content, Ratio and Productivity of Amphidinols in Wild-Type and Mutagenized Strains ofMarine drugs · 2026Article
- Conformational dynamics and molecular interactions of natural products: unveiling functional structures in biological membranes.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2025Review
- Sterolysin from a 1950s culture of Karlodinium veneficum (aka Gymnodinium veneficum Ballantine) forms lethal sterol dependent membrane pores.Scientific reports · 2024Article
- A Toxic Sterolysin From a 1950s Culture of Gymnodinium Veneficum Ballantine.Research square · 2024Article
- Lipid-Centric Approaches in Combating Infectious Diseases: Antibacterials, Antifungals and Antivirals with Lipid-Associated Mechanisms of Action.Antibiotics (Basel, Switzerland) · 2023Review
- Rapid Screening of Polyol Polyketides from Marine Dinoflagellates.Analytical chemistry · 2022Article
- Marine natural products targeting the eukaryotic cell membrane.The Journal of antibiotics · 2021Review
- Isolation and Structural Elucidation of New Amphidinol Analogues fromMarine drugs · 2021Article
- Amphidinol 3 preferentially binds to cholesterol in disordered domains and disrupts membrane phase separation.Biochemistry and biophysics reports · 2021Article
- Review
- High-speed atomic force microscopy highlights new molecular mechanism of daptomycin action.Nature communications · 2020Article
- Constitutive boost of a KProceedings of the National Academy of Sciences of the United States of America · 2018Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amphidinol 3 (AM3) is an anti-fungal polyene extracted from a marine dinoflagellate. Here, we examined the ion channel activity and membrane-embedded structure of AM3 using a lipid bilayer method and atomic force microscopy (AFM). AM3 exhibited large-conductance (~1 nS) and non-selective single-channel activity only when sterols were present in the membrane leaflet of the AM3-added side. The variable conductance suggests the formation of a multimeric barrel-stave pore. At high AM3 concentrations, giant-conductance "jumbo" channels (~40 nS) emerged. AFM revealed a thicker raft-like membrane phase with the appearance of a wrinkled surface, in which phase pores (diameter: ~10 nm) were observed. The flip-flop of ergosterol occurred only after the appearance of the jumbo channel, indicating that the jumbo channel induced a continuity between the outer and inner leaflets of the membrane: a feature characteristic of toroidal-like pores. Thus, AM3 forms different types of sterol-aided polymorphic channels in a concentration dependent manner.
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