ArticleScientific reports2017
A reminder before extinction strengthens episodic memory via reconsolidation but fails to disrupt generalized threat responses.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Role of Human Ventromedial Prefrontal Cortex in Learning and Recall of Enhanced Extinction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Trial
- Emotional intensity produces a linear relationship on conditioned learning but an inverted U-shaped effect on episodic memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Apparent reconsolidation interference without generalized amnesia.Progress in neuro-psychopharmacology & biological psychiatry · 2021Article
- Generalization and recovery of post-retrieval amnesia.Journal of experimental psychology. General · 2020Article
- Investigating the efficacy of the reminder-extinction procedure to disrupt contextual threat memories in humans using immersive Virtual Reality.Scientific reports · 2020Article
- No persistent attenuation of fear memories in humans: A registered replication of the reactivation-extinction effect.Cortex; a journal devoted to the study of the nervous system and behavior · 2020Article
- Impact of a reminder/extinction procedure on threat-conditioned pupil size and skin conductance responses.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Behavioral and neural processes in counterconditioning: Past and future directions.Behaviour research and therapy · 2020Review
- The effects of aversive-to-appetitive counterconditioning on implicit and explicit fear memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Patients with dorsolateral prefrontal cortex lesions are capable of discriminatory threat learning but appear impaired in cognitive regulation of subjective fear.Social cognitive and affective neuroscience · 2019Article
- Review
- Threat learning promotes generalization of episodic memory.Journal of experimental psychology. General · 2019Article
- From Extinction Learning to Anxiety Treatment: Mind the Gap.Brain sciences · 2019Article
- Aversive learning strengthens episodic memory in both adolescents and adults.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- Episodic memory and Pavlovian conditioning: ships passing in the night.Current opinion in behavioral sciences · 2019Article
- Propofol-induced deep sedation reduces emotional episodic memory reconsolidation in humans.Science advances · 2019Article
- Exploring the boundaries of post-retrieval extinction in healthy and anxious individuals.Behaviour research and therapy · 2018Article
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Authors and funding
5 authors.
Funding
Abstract
A reminder can temporarily renew flexibility of consolidated memories, referred to as reconsolidation. Pavlovian threat-conditioning studies suggest that a reminder can renew flexibility of threat responses but that episodic memories remain stable. In contrast, outside the threat-conditioning domain, studies testing memory for word lists or stories find that a reminder can renew flexibility of episodic memory. This discrepancy in findings leaves it unclear if episodic memories reconsolidate, or only Pavlovian responses. Here we unite the different approaches in the field and show that a reminder can retroactively strengthen episodic memory for Pavlovian threat-conditioned events, but that, in contrast to threat-conditioning studies with simple sensory stimuli, extinction after a reminder fails to prevent recovery of generalized threat responses. Our results indicate the episodic memories also reconsolidate, allowing strengthening of relevant memories. These findings also suggest that generalized threat responses and episodic memories are less susceptible to be modified by reminder-interventions procedures.
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Registered trials
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