ArticleScientific reports2017
Astrocytes and oligodendrocytes in grey and white matter regions of the brain metabolize fatty acids.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Nervonic acid supplementation mitigates disease severity biomarkers in adrenoleukodystrophy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Palmitic acid-induced autolysosomal dysfunction and lipotoxicity in neuroinflammation and neurodegeneration.Neural regeneration research · 2026Article
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- Sexual Dimorphisms in Neurodevelopment May Affect TBI Recovery in Pediatric Patients.Biomedicines · 2025Review
- Oligodendrocyte lineage cells dysfunction in depression: early life stress, adolescent vulnerability and the emerging role of lipid metabolism.Translational psychiatry · 2025Review
- High-precision cell-type mapping and annotation of single-cell spatial transcriptomics with STAMapper.Genome biology · 2025Article
- Comparative Brain and Serum Exosome Expression of Biomarkers in an Experimental Model of Alzheimer-Type Neurodegeneration: Potential Relevance to Liquid Biopsy Diagnostics.International journal of molecular sciences · 2025Article
- Deciphering the Blood-Brain Barrier Paradox in Brain Metastasis Development and Therapy.Cancers · 2025Review
- Evidence for white matter intrinsic connectivity networks at rest and during a task: A large-scale study and templates.Network neuroscience (Cambridge, Mass.) · 2025Article
- Spall: accurate and robust unveiling cellular landscapes from spatially resolved transcriptomics data using a decomposition network.BMC bioinformatics · 2024Article
- Effects of DHEA and DHEAS in Neonatal Hypoxic-Ischemic Brain Injury.Antioxidants (Basel, Switzerland) · 2024Article
- Brain and Serum Membrane Vesicle (Exosome) Profiles in Experimental Alcohol-Related Brain Degeneration: Forging the Path to Non-Invasive Liquid Biopsy Diagnostics.Journal of molecular pathology · 2024Article
- Brain Glucose Metabolism andDiagnostics (Basel, Switzerland) · 2024Article
- Characteristic BOLD signals are detectable in white matter of the spinal cord at rest and after a stimulus.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Spatially resolved transcriptome of the aging mouse brain.Aging cell · 2024Article
- Nervonic Acid Synthesis Substrates as Essential Components in Profiled Lipid Supplementation for More Effective Central Nervous System Regeneration.International journal of molecular sciences · 2024Review
- STZ-induced hyperglycemia differentially influences mitochondrial distribution and morphology in the habenulointerpeduncular circuit.Frontiers in cellular neuroscience · 2024Article
- Boltzmann's Theorem Revisited: Inaccurate Time-to-Action Clocks in Affective Disorders.Current neuropharmacology · 2024Review
- Review
- The Bidirectional Interplay of α-Synuclein with Lipids in the Central Nervous System and Its Implications for the Pathogenesis of Parkinson's Disease.International journal of molecular sciences · 2023Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The grey and white matter regions of the mammalian brain consist of both neurons and neuroglial cells. Among the neuroglia, the two macroglia oligodendrocytes and astrocytes are the most abundant cell types. While the major function of oligodendrocytes is the formation of the lipid-rich myelin structure, the heterogeneous group of astrocytes fulfils a multitude of important roles in cerebral development and homeostasis. Brain lipid homeostasis involves the synthesis of a specific cerebral lipidome by local lipid metabolism. In this study we have investigated the fatty acid uptake and lipid biosynthesis in grey and white matter regions of the murine brain. Key findings were: (i) white matter oligodendrocytes and astrocytes take up saturated and unsaturated fatty acids, (ii) different grey matter regions show varying lipid labelling intensities, (iii) the medial habenula, an epithalamic grey matter structure, and the oligodendrocytes and astrocytes therein are targeted by fatty acids, and (iv) in the medial habenula, the neutral lipid containing lipid droplets are found in cells facing the ventricle but undetectable in the habenular parenchyma. Our data indicate a role for oligodendrocytes and astrocytes in local lipid metabolism of white and grey matter regions in the brain.
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