Evidence map›Paper›PMID 28883473›Full record

ArticleScientific reports2017

Identification of Aspergillus fumigatus UDP-Galactopyranose Mutase Inhibitors.

Julia S Martin Del Campo, Meital Eckshtain-Levi, Nancy J Vogelaar, Pablo Sobrado

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Julia S Martin Del CampoDepartment of Biochemistry, Virginia Tech, Blacksburg, VA, 24061, USA.
Meital Eckshtain-LeviDepartment of Biochemistry, Virginia Tech, Blacksburg, VA, 24061, USA.
Nancy J VogelaarVirginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA, 24061, USA.
Pablo SobradoDepartment of Biochemistry, Virginia Tech, Blacksburg, VA, 24061, USA. psobrado@vt.edu.ORCID 0000-0003-1494-5382
Virginia Tech · US

Funding

Mechanistic and structural studies of eukaryotic UDP-galactopyranose mutasesR01GM094469 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI SOBRADO, PABLO, TANNER, JOHN J · 2010 to 2019
$2.0M
NIGMS NIH HHS R01 GM094469
6 · The paper itself

Abstract

Aspergillus fumigatus is an opportunistic human pathogen responsible for deadly, invasive infections in immunocompromised patients. The A. fumigatus cell wall is a complex network of polysaccharides among them galactofuran, which is absent in humans. UDP-galactopyranose mutase (UGM) catalyzes the conversion of UDP-galactofuranose (UDP-Galf) to UDP-galactopyranose (UDP-Galp) and is an important virulence factor. UGM is a flavin-dependent enzyme that requires the reduced flavin for activity; flavin reduction is achieved by reaction with NADPH. The aim of this work was to discover inhibitors of UGM by targeting the NADPH binding site using an ADP-TAMRA probe in a high-throughput screening assay. The flavonoids (2S)-hesperetin and (2S)-naringenin were validated as competitive inhibitors of UGM against NADPH with K

Identifiers

PMID28883473
PMCPMC5589893
OpenAlexW2753379868

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.