SynthesisScientific reports2017
The Relationship between Hematological Indices and Autoimmune Rheumatic Diseases (ARDs), a Meta-Analysis.
Synthesis in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association Between Hematological Indices of Inflammation and Pathogenesis and Prognosis of Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-Analysis.The journal of international advanced otology · 2025Pooled it
- Pooled it
- The Impact of Neutrophil-Lymphocyte Ratio in Febrile Seizures: A Systematic Review and Meta-Analysis.BioMed research international · 2022Pooled it
- Applicability of common inflammatory markers in diagnosing infections in early period after liver transplantation in intensive care setting.Scientific reports · 2020Trial
- The clinical value of hematological markers in rheumatoid arthritis patients treated with tocilizumab.Journal of clinical laboratory analysis · 2019Trial
- Association of Inflammatory and Nutritional Biomarkers in Children with Febrile Seizures: A Case-Control Study of NLR, PNI, and CAR.Diagnostics (Basel, Switzerland) · 2026Article
- Diagnostic Potential of New Systemic Inflammation Markers (MLR, SIRI, CAR, dNLR, ALB/dNLR) in Predicting the Severity of Pathogenic Signs of Rheumatoid Arthritis.Sovremennye tekhnologii v meditsine · 2026Article
- Oxidative Stress and Cirrhosis Severity: A Retrospective Cohort Analysis of Predictive and Interactive Effects with Inflammation.Metabolites · 2025Article
- The association and clinical significance of hematological biomarkers in ankylosing spondylitis.Scientific reports · 2025Article
- First Trimester Hematological Indices in Gestational Diabetes Mellitus: A Meta-Analysis.Journal of the Endocrine Society · 2025Review
- Associations between neonicotinoids and inflammation in US adults using hematological indices: NHANES 2015-2016.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- Observational
- Neutrophil-to-lymphocyte ratio as a prognostic indicator in COVID-19: Evidence from a northern tanzanian cohort.PloS one · 2025Article
- Aberrant DNA Methylation Profile of Dickkopf-1 in Ankylosing Spondylitis.Biochemical genetics · 2024Article
- Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio Predicts the Disease Activity in Patients with Paediatric Systemic Lupus Erythematosus: An Observational Cross-Sectional Study.Mediterranean journal of rheumatology · 2024Article
- Complete Blood Collection-based Systemic Inflammation Biomarkers as a Severity Biomarker in Alopecia Areata: A Cross-sectional Study.Acta dermato-venereologica · 2024Article
- Association of neutrophil defects with oral ulcers but undetermined role of neutrophils in recurrent aphthous stomatitis.Heliyon · 2024Review
- Efficacy of the cardiac glycoside digoxin as an adjunct to csDMARDs in rheumatoid arthritis patients: a randomized, double-blind, placebo-controlled trial.Frontiers in pharmacology · 2024Article
- Correlation of Hematological Indices and Acute-Phase Reactants in Rheumatoid Arthritis Patients on Disease-Modifying Antirheumatic Drugs: A Retrospective Cohort Analysis.Journal of clinical medicine · 2023Article
- Role of Hematological Parameters in the Grading of COVID-19 and a Model to Predict the Outcome in Inpatients.Cureus · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This meta-analysis was undertaken to investigate the relationship between hematological indices and autoimmune rheumatic diseases (ARDs). PubMed, Embase, and Web of Science were searchedfor studies of ARDs and hematological indices. Standardized mean difference (SMD) was calculated with confidence interval (CI) of 95%. 18 studies were included in our meta-analysis. Compared to the healthy control group, neutrophil-lymphocyte ratio (NLR) was increased in patients with ankylosing spongdylitis(AS), Behçet's disease(BD), andrheumatoid arthritis(RA)(SMD = 0.33; 95% CI: 0.19 to 0.47; SMD = 1.90; 95% CI: 0.13 to 3.67; SMD = 0.75; 95% CI: 0.23 to 1.28). Platelet-lymphocyte ratio (PLR) was found increased in RA and SLE (SMD = 33.91; 95% CI: 20.50 to 47.32; SMD = 59.11; 95% CI: 4.46 to 113.76). Mean platelet volume (MPV)was irrelevant to BD and SLE by comparing with the healthy control group respectively. (SMD = 0.24; 95% CI: -0.49 to 0.97; SMD = -0.15; 95% CI: -1.77 to 1.48). Red cell distribution width (RDW) was not related to AS (SMD = 0.59, 95% CI: -0.37, 1.55). Our findings indicated that NLR had a strong association with AS, BD, and RA. PLR was also related to RA and SLE. NLR and PLR could be recommended as inexpensive diagnostic biomarkers for ARDs.
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