ArticleScientific reports2017
Loss of brain inter-frequency hubs in Alzheimer's disease.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 106 citations in OpenAlex.
- Structural-functional multilayer brain network properties and outcome of combined repetitive transcranial magnetic stimulation and psychotherapy for obsessive-compulsive disorder.NeuroImage. Clinical · 2026Trial
- A qualitative exploration of 40 Hz sound and music for older adults with mild cognitive impairment.Geriatric nursing (New York, N.Y.)Trial
- Neurobiological mechanisms of 40-Hz stimulation in Alzheimer's disease: evidence, heterogeneity, and constraints.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Alzheimer's Disease as a Multi-Layer Network Disorder: A Systems Biology Framework Integrating Multi-Omics Mechanisms.Biomedicines · 2026Review
- Machine-enhanced reconstruction of functional connectomes unravels discriminative brain sub-systems in health and disease.Scientific reports · 2026Article
- Structure-function multilayer network integration and cognition in multiple sclerosis.Network neuroscience (Cambridge, Mass.) · 2026Article
- Self-organization and circular causation as synergetic foundations of social interaction: a multilayer network perspective.Frontiers in network physiology · 2026Article
- Musicians' brains at rest: multilayer network analysis of magnetoencephalography data.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Spectral Biomarkers of Functional Brain Network Alteration in Alzheimer's Disease.Current Alzheimer research · 2025Observational
- Topological Biomarkers of Alzheimer's Disease from Functional Brain Network Analysis.Current Alzheimer research · 2025Article
- Multilayer network analysis in patients with end-stage kidney disease.Scientific reports · 2024Article
- Multilayer network analysis in patients with juvenile myoclonic epilepsy.Neuroradiology · 2024Article
- Node-layer duality in networked systems.Nature communications · 2024Article
- Transcranial alternating current stimulation (tACS) at gamma frequency: an up-and-coming tool to modify the progression of Alzheimer's Disease.Translational neurodegeneration · 2024Review
- Dopamine neuron degeneration in the Ventral Tegmental Area causes hippocampal hyperexcitability in experimental Alzheimer's Disease.Molecular psychiatry · 2024Article
- Linking structural and functional changes during aging using multilayer brain network analysis.Communications biology · 2024Article
- Safety, tolerability, and efficacy estimate of evoked gamma oscillation in mild to moderate Alzheimer's disease.Frontiers in neurology · 2024Article
- Functional network disruption in cognitively unimpaired autosomal dominant Alzheimer's disease: a magnetoencephalography study.Brain communications · 2024Article
- Hub overload and failure as a final common pathway in neurological brain network disorders.Network neuroscience (Cambridge, Mass.) · 2024Review
- Multilayer network changes in patients with migraine.Brain and behavior · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD) causes alterations of brain network structure and function. The latter consists of connectivity changes between oscillatory processes at different frequency channels. We proposed a multi-layer network approach to analyze multiple-frequency brain networks inferred from magnetoencephalographic recordings during resting-states in AD subjects and age-matched controls. Main results showed that brain networks tend to facilitate information propagation across different frequencies, as measured by the multi-participation coefficient (MPC). However, regional connectivity in AD subjects was abnormally distributed across frequency bands as compared to controls, causing significant decreases of MPC. This effect was mainly localized in association areas and in the cingulate cortex, which acted, in the healthy group, as a true inter-frequency hub. MPC values significantly correlated with memory impairment of AD subjects, as measured by the total recall score. Most predictive regions belonged to components of the default-mode network that are typically affected by atrophy, metabolism disruption and amyloid-β deposition. We evaluated the diagnostic power of the MPC and we showed that it led to increased classification accuracy (78.39%) and sensitivity (91.11%). These findings shed new light on the brain functional alterations underlying AD and provide analytical tools for identifying multi-frequency neural mechanisms of brain diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.