Evidence map›Paper›PMID 28883017›Full record

ArticleDisease models & mechanisms2017

NFκB signaling in alveolar rhabdomyosarcoma.

Megan M Cleary, Atiya Mansoor, Teagan Settelmeyer, Yuichi Ijiri, Katherine J Ladner, Matthew N Svalina, Brian P Rubin, Denis C Guttridge, Charles Keller

Open access · goldAbstract read
In one paragraph

Article in Disease models & mechanisms, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Megan M ClearyChildren's Cancer Therapy Development Institute, Beaverton, OR 97005, USA megan@cc-tdi.org denis.guttridge@osumc.edu charles@cc-tdi.org.
Atiya MansoorDepartment of Pathology, Oregon Health and Science University, Portland, OR 97239, USA.
Teagan SettelmeyerChildren's Cancer Therapy Development Institute, Beaverton, OR 97005, USA.
Yuichi IjiriDepartment of Cancer Biology and Genetics and The Arthur G. James Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH 43210, USA.
Katherine J LadnerDepartment of Cancer Biology and Genetics and The Arthur G. James Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH 43210, USA.
Matthew N SvalinaChildren's Cancer Therapy Development Institute, Beaverton, OR 97005, USA.
Brian P RubinDepartment of Anatomic Pathology, Department of Molecular Genetics, Taussig Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
Denis C GuttridgeDepartment of Cancer Biology and Genetics and The Arthur G. James Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH 43210, USA megan@cc-tdi.org denis.guttridge@osumc.edu charles@cc-tdi.org.
Charles KellerChildren's Cancer Therapy Development Institute, Beaverton, OR 97005, USA megan@cc-tdi.org denis.guttridge@osumc.edu charles@cc-tdi.org.
Children's Cancer Therapy Development Institute · USThe Ohio State University · USCleveland Clinic · USOregon Health & Science University · USThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · US

Funding

Elucidating the role of NF-kB signaling in rhabdomyocarcomaR01CA143082 · NCI · OHIO STATE UNIVERSITY · PI GUTTRIDGE, DENIS C, KELLER, CHARLES · 2011 to 2015
$1.6M
NCI NIH HHS R01 CA143082
6 · The paper itself

Abstract

Alveolar rhabdomyosarcoma (aRMS) is a pediatric soft tissue cancer commonly associated with a chromosomal translocation that leads to the expression of a Pax3:Foxo1 or Pax7:Foxo1 fusion protein, the developmental underpinnings of which may give clues to its therapeutic approaches. In aRMS, the NFκB-YY1-miR-29 regulatory circuit is dysregulated, resulting in repression of

Indexed as

Signal TransductionAllograftsAnimalsCell Line, TumorCell ProliferationDogsFemaleGene DeletionGenetic Complementation TestHumansI-kappa B KinaseMice, SCIDNF-kappa BPeptidesPhenotypeProto-Oncogene Proteins c-bcl-2I-kappa B KinaseNF-kappa BPeptidesProto-Oncogene Proteins c-bcl-2CancerIKKβNFκBRhabdomyosarcoma

Identifiers

PMID28883017
PMCPMC5611971
OpenAlexW2753327912

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.