Evidence map›Paper›PMID 28882932›Full record

ArticleBMJ case reports2017

Hickam's dictum: Myasthenia Gravis presenting concurrently with Graves' disease.

Shekhar Sehgal, Roshan Rebello, Louise Wolmarans, Marianne Elston

Abstract readCase Reports
In one paragraph

Article in BMJ case reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Shekhar SehgalDepartment of Endocrinology, Waikato Hospital, Hamilton, New Zealand.
Roshan RebelloDepartment of Endocrinology, Waikato Hospital, Hamilton, New Zealand.
Louise WolmaransDepartment of Endocrinology, Waikato Hospital, Hamilton, New Zealand.
Marianne ElstonDepartment of Endocrinology, Waikato Hospital, Hamilton, New Zealand.ORCID http://orcid.org/0000-0002-0748-2300
Waikato Hospital · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present two patients with Graves' disease and concurrent myasthenia gravis. The impact of the dual diagnosis on the clinical course and the potential for a delayed diagnosis of myasthenia gravis is discussed. Patient 1, a 28-year-old man was diagnosed with Graves' disease following his second respiratory arrest. His history was strongly suggestive of a second pathology. Patient 2, a 66-year-old Cantonese woman with established Graves' disease presented with thionamide-related neutropaenia. Examination revealed bilateral ptosis and right lateral rectus palsy. Both patients had thyrotoxicosis secondary to Graves' disease with concurrent myasthenia gravis. Although neuromuscular weakness is common in Graves' disease, coexisting myasthenia gravis (MG) is rare and can cause profound morbidity. Ocular signs in both diseases may cause diagnostic confusion although ptosis suggests coexisting MG. In both cases, the thyrotoxicosis delayed the diagnosis of MG.

Indexed as

AdultAgedAntithyroid AgentsBlepharoptosisCarbimazoleCholinesterase InhibitorsFemaleGraves DiseaseHumansInfusions, IntravenousMagnetic Resonance ImagingMaleMyasthenia GravisPyridostigmine BromideThyrotoxicosisTreatment OutcomeAntithyroid AgentsCarbimazoleCholinesterase InhibitorsPyridostigmine Bromidemuscle diseasethyroid disease

Identifiers

PMID28882932
PMCPMC5589050
OpenAlexW2751846567

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.