SynthesisBMJ open2017
Incidence of laboratory-confirmed influenza disease among infants under 6 months of age: a systematic review.
Synthesis in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07243236 ("Assessment of the Impact of Vaccine Funding by the National Health Insurance on Vaccination Coverage Among Patients Targeted by Current Vaccination Recommendations and Followed in Outpatient Consultations in Ile-de-France Region in France""), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
"Assessment of the Impact of Vaccine Funding by the National Health Insurance on Vaccination Coverage Among Patients Targeted by Current Vaccination Recommendations and Followed in Outpatient Consultations in Ile-de-France Region in France""
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Spotlight influenza: Laboratory-confirmed seasonal influenza in people with acute respiratory illness: a literature review and meta-analysis, WHO European Region, 2004 to 2017.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2021Pooled it
- Estimating cumulative incidence from partially missing time series of respiratory viral infections.PloS one · 2026Article
- Heterogeneity in seasonal influenza vaccination opportunity and disease risk during pregnancy and in infants <6 months.Vaccine · 2025Article
- Cocooning Vaccination Strategy for Infants.Indian pediatrics · 2025Article
- Maternal and Neonatal Outcomes of Pregnant Women With Seasonal Influenza, A Single-Center Study.Journal of family & reproductive health · 2025Article
- Disease burden and high-risk populations for complications in patients with acute respiratory infections: a scoping review.Frontiers in medicine · 2024Article
- Lessons learned from the A (H1N1) influenza pandemic.Best practice & research. Clinical obstetrics & gynaecology · 2021Review
- Oseltamivir treatment of influenza A and B infections in infants.Influenza and other respiratory viruses · 2021Article
- Burden of influenza during the first year of life.Influenza and other respiratory viruses · 2021Article
- Estimated impact of maternal vaccination on global paediatric influenza-related in-hospital mortality: A retrospective case series.EClinicalMedicine · 2021Article
- Incidence, risk factors and impact of seasonal influenza in pregnancy: A national cohort study.PloS one · 2021Article
- The burden and clinical manifestation of hospitalized influenza among different pediatric age-groups in the tropics.Influenza and other respiratory viruses · 2020Article
- Coverage and determinants of influenza vaccine among pregnant women: a cross-sectional study.BMC public health · 2019Article
- Article
- Influenza epidemiology and immunization during pregnancy: Final report of a World Health Organization working group.Vaccine · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
objectivesThe aim of this systematic review was to assess incidence rates of laboratory-confirmed influenza (LCI) outcomes among infants under 6 months of age.
designSystematic literature search and review of indexed studies in PubMed, EMBASE, the Cochrane Library and CINAHL Plus from inception to 19 April 2017.
settingPopulation-based estimates from community or hospital settings.
participantsInfants under 6 months of age. PRIMARY AND SECONDARY OUTCOME MEASURES: LCI illness in ambulatory care settings, LCI hospitalisation, LCI intensive care unit admission and LCI death. Only studies with population-based incidence data were included.
resultsWe identified 27 primary studies, 11 of which were from the USA, four were from other non-US high-income settings and the remaining were from lower-middle-income or upper-middle-income countries. Most studies (n=23) assessed incidence of LCI hospitalisation, but meta-analysis to pool study-specific rates was not possible due to high statistical and methodological heterogeneity. Among US studies, the reported incidence of LCI hospitalisation ranged from 9.3 to 91.2 per 10 000 infants under 6 months for seasonal influenza, while the only US-based estimate for pandemic H1N1 influenza was 20.2 per 10 000 infants. Reported rates for LCI hospitalisation for seasonal influenza from other countries ranged from 6.2 to 73.0 per 10 000 infants under 6 months, with the exception of one study with an estimated rate of 250 per 10 000 infants. No events were reported in five of the nine studies that evaluated LCI death among infants under 6 months.
conclusionOur review of published studies found limited data on LCI outcomes for infants under 6 months, particularly from non-US settings. Globally representative and reliable incidence data are necessary to fully evaluate influenza disease burden and the potential impact of maternal influenza immunisation programme on morbidity and mortality in young infants.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.