Evidence map›Paper›PMID 28882892›Full record

ArticleThe Journal of biological chemistry2017

Structural features of human inositol phosphate multikinase rationalize its inositol phosphate kinase and phosphoinositide 3-kinase activities.

Huanchen Wang, Stephen B Shears

Open access · hybridAbstract readComparative Study
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Structural Rationalization of IPMK Inhibitor Potency.Journal of medicinal chemistry · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Arg1 frommBio · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. The Inositol Phosphate System-A Coordinator of Metabolic Adaptability.International journal of molecular sciences · 2022
    Review
  16. Article
  17. Review
  18. Review
  19. Inositol phosphate kinases in the eukaryote landscape.Advances in biological regulation · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Huanchen WangFrom the Inositol Signaling Group, Signal Transduction Laboratory, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709 wangh7@niehs.nih.gov.
Stephen B ShearsFrom the Inositol Signaling Group, Signal Transduction Laboratory, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709.
National Institute of Environmental Health Sciences · USTriangle · US

Funding

Inositol SignallingZIAES080046 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SHEARS, STEPHEN B · 2009 to 2023
$31.3M
6 · The paper itself

Abstract

Human inositol phosphate multikinase (

Indexed as

Models, MolecularAmino Acid SequenceAmino Acid SubstitutionBinding SitesCarbohydrate ConformationCatalytic DomainConserved SequenceCrystallography, X-RayHumansInositol 1,4,5-TrisphosphateInositol PhosphatesMutagenesis, Site-DirectedMutationPhosphotransferases (Alcohol Group Acceptor)Protein ConformationProtein Interaction Domains and MotifsInositol 1,4,5-Trisphosphateinositol 4,5-bisphosphateInositol Phosphatesinositol polyphosphate multikinasePhosphotransferases (Alcohol Group Acceptor)Recombinant Proteinsenzyme catalysisinositol phosphatekinasephosphatidylinositol kinase (PI kinase)phosphatidylinositol signalingprotein kinase A (PKA)signalingsubstrate specificityX-ray crystallography

Identifiers

PMID28882892
PMCPMC5672042
OpenAlexW2752132413

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.