Evidence map›Paper›PMID 28882825›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2018

Hepatocyte nuclear factor 4α regulates the expression of intestinal epithelial Na

Saminathan Muthusamy, Jong Jin Jeong, Ming Cheng, Jessica A Bonzo, Anoop Kumar, Frank J Gonzalez, Alip Borthakur, Pradeep K Dudeja, Seema Saksena, Jaleh Malakooti

Abstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
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  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Saminathan MuthusamyDivision of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago , Chicago, Illinois.
Jong Jin JeongDivision of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago , Chicago, Illinois.
Ming ChengDivision of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago , Chicago, Illinois.
Jessica A BonzoCenter for Cancer Research, National Cancer Institute , Bethesda, Maryland.
Anoop KumarDivision of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago , Chicago, Illinois.
Frank J GonzalezCenter for Cancer Research, National Cancer Institute , Bethesda, Maryland.
Alip BorthakurDivision of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago , Chicago, Illinois.ORCID 0000-0002-5792-1279
Pradeep K DudejaDivision of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago , Chicago, Illinois.
Seema SaksenaDivision of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago , Chicago, Illinois.
Jaleh MalakootiJesse Brown Veterans Affairs Medical Center , Chicago, Illinois.

Funding

Xenobiotic receptorsZIABC005562 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GONZALEZ, FRANK J · 2009 to 2025
$26.9M
Intestinal Anion Transporters: Function and RegulationR01DK054016 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DUDEJA, PRADEEP K · 1998 to 2022
$7.0M
Transporter Trafficking Mechanisms in Infectious DiarrheaR01DK092441 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DUDEJA, PRADEEP K · 2011 to 2020
$3.0M
Probiotics:Potential Therapeutic Roles in DiarrheaR01DK081858 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DUDEJA, PRADEEP K · 2008 to 2017
$2.5M
Mechanisms of Regulation of Intestinal Cl Absorption in IBD Associated DiarrheaI01BX002011 · VA · JESSE BROWN VA MEDICAL CENTER · PI DUDEJA, PRADEEP K · 2013 to 2024
–
Regulation of Intestinal Sodium Absorption in Health and DiseaseI01BX002867 · VA · JESSE BROWN VA MEDICAL CENTER · PI Seema Saksena · 2016 to 2026
–
BLRD VA I01 BX002011BLRD VA I01 BX002687BLRD VA I01 BX002867NIDDK NIH HHS R01 DK054016NIDDK NIH HHS R01 DK081858NIDDK NIH HHS R01 DK092441
6 · The paper itself

Abstract

Na

Indexed as

Binding SitesCaco-2 CellsGene Expression RegulationHCT116 CellsHepatocyte Nuclear Factor 4HumansIntestinal MucosaPromoter Regions, GeneticProtein BindingSodium-Hydrogen Exchanger 3Hepatocyte Nuclear Factor 4HNF4A protein, humanSLC9A3 protein, humanSodium-Hydrogen Exchanger 3C2BBe1 cellsHnf4aΔIEpC miceNaCl absorptiontranscriptional regulation

Identifiers

PMID28882825
PMCPMC5866373

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.