Evidence map›Paper›PMID 28882628›Full record

ReviewNeuroImage2018

An exemplar-based approach to individualized parcellation reveals the need for sex specific functional networks.

Mehraveh Salehi, Amin Karbasi, Xilin Shen, Dustin Scheinost, R Todd Constable

Abstract readReview
In one paragraph

Review in NeuroImage, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Reproducible sex differences in personalised functional network topography in youth.The British journal of psychiatry : the journal of mental science · 2025
    Article
  3. Article
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  9. Review
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  15. Article
  16. Heritability of individualized cortical network topography.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  17. Review
  18. Regions and Connections: Complementary Approaches to Characterize Brain Organization and Function.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2020
    Review
  19. Article
  20. Machine learning in resting-state fMRI analysis.Magnetic resonance imaging · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mehraveh SalehiDepartment of Electrical Engineering, Yale University, New Haven, CT, USA; Yale Institute for Network Science, Yale University, New Haven, CT, USA. Electronic address: mehraveh.salehi@yale.edu.
Amin KarbasiDepartment of Electrical Engineering, Yale University, New Haven, CT, USA; Yale Institute for Network Science, Yale University, New Haven, CT, USA.
Xilin ShenDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Dustin ScheinostDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
R Todd ConstableInterdepartmental Neuroscience Program, Yale University, New Haven, CT, USA; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA; Department of Neurosurgery, Yale School of Medicine, New Haven, CT, USA.

Funding

Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
Understanding evoked and resting-state fMRI through multi scale imagingR01MH111424 · NIMH · YALE UNIVERSITY · PI CONSTABLE, R TODD, CRAIR, MICHAEL C. · 2016 to 2020
$5.2M
Multiscale Imaging of Spontaneous Activity in Cortex: Mechanisms, Development and FunctionU01NS094358 · NINDS · YALE UNIVERSITY · PI CONSTABLE, R TODD, CRAIR, MICHAEL C. · 2015 to 2017
$4.6M
Method for Measuring Functional Subunits in Human CortexR01EB009666 · NIBIB · YALE UNIVERSITY · PI CONSTABLE, R TODD · 2010 to 2013
$1.4M
NIBIB NIH HHS R01 EB009666NIMH NIH HHS R01 MH111424NIMH NIH HHS U54 MH091657NINDS NIH HHS U01 NS094358
6 · The paper itself

Abstract

Recent work with functional connectivity data has led to significant progress in understanding the functional organization of the brain. While the majority of the literature has focused on group-level parcellation approaches, there is ample evidence that the brain varies in both structure and function across individuals. In this work, we introduce a parcellation technique that incorporates delineation of functional networks both at the individual- and group-level. The proposed technique deploys the notion of "submodularity" to jointly parcellate the cerebral cortex while establishing an inclusive correspondence between the individualized functional networks. Using this parcellation technique, we successfully established a cross-validated predictive model that predicts individuals' sex, solely based on the parcellation schemes (i.e. the node-to-network assignment vectors). The sex prediction finding illustrates that individualized parcellation of functional networks can reveal subgroups in a population and suggests that the use of a global network parcellation may overlook fundamental differences in network organization. This is a particularly important point to consider in studies comparing patients versus controls or even patient subgroups. Network organization may differ between individuals and global configurations should not be assumed. This approach to the individualized study of functional organization in the brain has many implications for both neuroscience and clinical applications.

Indexed as

BrainModels, TheoreticalNerve NetSex CharacteristicsAdultBrain MappingFemaleHumansImage Processing, Computer-AssistedMaleExemplar-based clusteringFunctional parcellationHuman connectome projectIndividual differencesPredictive modelingSex differencesSubmodularity

Identifiers

PMID28882628
PMCPMC5905726

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.