ReviewMolecular and cellular endocrinology2018
The impact of androgen actions in neurons on metabolic health and disease.
Review in Molecular and cellular endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- A meta-analysis of dizziness as an adverse reaction in novel endocrine therapy for advanced prostate cancer.BMC cancer · 2026Pooled it
- Mapping research trends of insulin resistance in polycystic ovary syndrome from 2017 to 2021: A bibliometric analysis.Frontiers in endocrinology · 2022Pooled it
- Sexual dimorphism in the development and function of the melanocortin system.Reviews in endocrine & metabolic disorders · 2026Review
- Exploring the shared genetic architecture between testosterone traits and major depressive disorder.BMC psychiatry · 2025Article
- Ten simple rules for queer data collection and analysis by STEM researchers.PLoS computational biology · 2025Article
- Androgens as the "old age stick" in skeletal muscle.Cell communication and signaling : CCS · 2025Review
- Integrated single-cell and spatial transcriptomics reveal microenvironment disruptions by androgen in mouse ovary.iScience · 2024Article
- Androgen receptor monomers and dimers regulate opposing biological processes in prostate cancer cells.Nature communications · 2024Article
- Sex-specific responses in glucose-insulin homeostasis and lipoprotein-lipid components after high-dose supplementation with marine n-3 PUFAs in abdominal obesity: a randomized double-blind crossover study.Frontiers in nutrition · 2023Article
- The role of testosterone, the androgen receptor, and hypothalamic-pituitary-gonadal axis in depression in ageing Men.Reviews in endocrine & metabolic disorders · 2022Review
- Androgen Excess Increases Food Intake in a Rat Polycystic Ovary Syndrome Model by Downregulating Hypothalamus Insulin and Leptin Signaling Pathways Preceding Weight Gain.Neuroendocrinology · 2022Article
- The transcriptome pattern of liver, spleen and hypothalamus provides insights into genetic and biological changes in roosters in response to castration.Frontiers in genetics · 2022Article
- Association of Second-generation Antiandrogens With Depression Among Patients With Prostate Cancer.JAMA network open · 2021Article
- Sympathetic Innervation of White Adipose Tissue: to Beige or Not to Beige?Physiology (Bethesda, Md.) · 2021Article
- Pomc Plays an Important Role in Sexual Size Dimorphism in Tilapia.Marine biotechnology (New York, N.Y.) · 2021Article
- Plasma androgens and the presence and course of depression in a large cohort of women.Translational psychiatry · 2021Article
- Insulin resistance and PCOS: chicken or egg?Journal of endocrinological investigation · 2021Review
- Mitochondria in Sex Hormone-Induced Disorder of Energy Metabolism in Males and Females.Frontiers in endocrinology · 2021Review
- Sex as a Biological Variable: A 5-Year Progress Report and Call to Action.Journal of women's health (2002) · 2020Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The male hormone testosterone exerts different effects on glucose and energy homeostasis in males and females. Testosterone deficiency predisposes males to visceral obesity, insulin resistance and type 2 diabetes. However, testosterone excess predisposes females to similar metabolic dysfunction. Here, we review the effects of testosterone actions in the central nervous system on metabolic function in males and females. In particular, we highlight changes within the hypothalamus that control glucose and energy homeostasis. We distinguish the organizational effects of testosterone in the programming of neural circuitry during development from the activational effects of testosterone during adulthood. Finally, we explore potential sites where androgen might be acting to impact metabolism within the central nervous system.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.