Evidence map›Paper›PMID 28882473›Full record

ArticleHormones and behavior2017

Age-related changes in sexual function and steroid-hormone receptors in the medial preoptic area of male rats.

Victoria L Nutsch, Ryan G Will, Daniel J Tobiansky, Michael P Reilly, Andrea C Gore, Juan M Dominguez

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hormones and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Victoria L NutschInstitute for Neuroscience, The University of Texas at Austin, Austin, TX, USA.
Ryan G WillDepartment of Psychology, The University of Texas at Austin, Austin, TX, USA.
Daniel J TobianskyDepartment of Psychology, The University of Texas at Austin, Austin, TX, USA.
Michael P ReillyDivision of Pharmacology and Toxicology, The University of Texas at Austin, Austin, TX, USA.
Andrea C GoreInstitute for Neuroscience, The University of Texas at Austin, Austin, TX, USA; Department of Psychology, The University of Texas at Austin, Austin, TX, USA; Division of Pharmacology and Toxicology, The University of Texas at Austin, Austin, TX, USA. Electronic address: andrea.gore@austin.utexas.edu.
Juan M DominguezInstitute for Neuroscience, The University of Texas at Austin, Austin, TX, USA; Department of Psychology, The University of Texas at Austin, Austin, TX, USA; Division of Pharmacology and Toxicology, The University of Texas at Austin, Austin, TX, USA. Electronic address: dominguez@utexas.edu.
The University of Texas at Austin · US

Funding

The Nonhuman Primate CoreP01AG016765 · NIA · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI MORRISON, JOHN H. · 1999 to 2016
$26.1M
A Role for the Preoptic Area in Modulating Cocaine RewardR01DA032789 · NIDA · UNIVERSITY OF TEXAS AT AUSTIN · PI DOMINGUEZ, JUAN M · 2012 to 2016
$1.5M
NIA NIH HHS P01 AG016765NIDA NIH HHS R01 DA032789
6 · The paper itself

Abstract

Testosterone is the main circulating steroid hormone in males, and acts to facilitate sexual behavior via both reduction to dihydrotestosterone (DHT) and aromatization to estradiol. The mPOA is a key site involved in mediating actions of androgens and estrogens in the control of masculine sexual behavior, but the respective roles of these hormones is not fully understood. As males age they show impairments in sexual function, and a decreased facilitation of behavior by steroid hormones compared to younger animals. We hypothesized that an anatomical substrate for these behavioral changes is a decline in expression and/or activation of hormone receptor-sensitive cells in the mPOA. We tested this by quantifying and comparing numbers of AR- and ERα-containing cells, and Fos as a marker of activated neurons, in the mPOA of mature (4-5months) and aged (12-13months) male rats, assessed one hour after copulation to one ejaculation. Numbers of AR- and ERα cells did not change with age or after sex, but the percentage of AR- and ERα-cells that co-expressed Fos were significantly up-regulated by sex, independent of age. Age effects were found for the percentage of Fos cells that co-expressed ERα (up-regulated in the central mPOA) and the percentage of Fos cells co-expressing AR in the posterior mPOA. Interestingly, serum estradiol concentrations positively correlated with intromission latency in aged but not mature animals. These data show that the aging male brain continues to have high expression and activation of both AR and ERα in the mPOA with copulation, raising the possibility that differences in relationships between hormones, behavior, and neural activation may underlie some age-related impairments.

Indexed as

AgingAnimalsDihydrotestosteroneEstradiolMaleNeuronsPreoptic AreaRatsRats, Sprague-DawleyReceptors, AndrogenReceptors, EstrogenSexual Behavior, AnimalTestosteroneDihydrotestosteroneEstradiolReceptors, AndrogenReceptors, EstrogenTestosteroneAgingAndrogen receptorEstradiolEstrogen receptor alphaMalePreoptic area

Identifiers

PMID28882473
PMCPMC5722693
OpenAlexW2754795589

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.