ArticleNeurobiology of aging2017
Associations between dynamic functional connectivity and age, metabolic risk, and cognitive performance.
Article in Neurobiology of aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Go with the (Blood) Flow: A Systematic Review on the Relationship Between Dynamic Functional Connectivity and Information Processing Speed.Neuropsychology review · 2026Pooled it
- The older adult brain is less modular, more integrated, and less efficient at rest: A systematic review of large-scale resting-state functional brain networks in aging.Psychophysiology · 2023Pooled it
- Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS.Scientific reports · 2022Trial
- Arousal-driven critical roaming reproduces human functional connectivity dynamics.PLoS biology · 2026Article
- A local-to-distant shift in dynamic brain connectivity marks early Alzheimer's risk.GeroScience · 2026Article
- Altered Brain Dynamics in Heavy Smokers Revealed by Dynamic Functional Network Connectivity Analysis.Brain topography · 2026Article
- Dynamic reconfigurations of brain subnetworks in female patients with alcohol use disorder or bulimia nervosa: a resting-state functional magnetic resonance imaging study.European archives of psychiatry and clinical neuroscience · 2025Article
- State-Guided ICA of Functional Network Connectivity Reveals Temporal Signatures of Alzheimer's Disease.medRxiv : the preprint server for health sciences · 2025Article
- Dynamic Functional Network Connectivity Pattern of the Amygdalohippocampal Complex in Individuals With Subjective Cognitive Decline.Human brain mapping · 2025Article
- Cognitive and psychiatric relevance of dynamic functional connectivity states in a large (N > 10,000) children population.Molecular psychiatry · 2025Article
- Altered dynamic functional network connectivity patterns in Alzheimer's disease: insights into neural dysfunction.Frontiers in aging neuroscience · 2025Article
- Dynamic functional connectivity of the amygdala-hippocampal complex is associated with cognitive impairment in adolescents with Internet gaming disorder.Frontiers in psychiatry · 2025Article
- Alterations in Dynamic Functional Connectivity in Patients with Cerebral Small Vessel Disease.Translational stroke research · 2024Article
- Impaired Neurovascular Coupling and Increased Functional Connectivity in the Frontal Cortex Predict Age-Related Cognitive Dysfunction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Cognitive and Psychiatric Relevance of Dynamic Functional Connectivity States in a Large (N>10,000) Children Population.Research square · 2024Article
- Aberrant dynamic functional network connectivity in type 2 diabetes mellitus individuals.Cognitive neurodynamics · 2023Article
- Age-dependent changes in the dynamic functional organization of the brain at rest: a cross-cultural replication approach.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Stability of sensorimotor network sculpts the dynamic repertoire of resting state over lifespan.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Age Related Functional Connectivity Signature Extraction Using Energy-Based Machine Learning Techniques.Sensors (Basel, Switzerland) · 2023Article
- Altered dynamic functional network connectivity in levodopa-induced dyskinesia of Parkinson's disease.CNS neuroscience & therapeutics · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Advanced age is associated with reduced within-network functional connectivity, particularly within the default mode network. Most studies to date have examined age differences in functional connectivity via static indices that are computed over the entire blood-oxygen-level dependent time series. Little is known about the effects of age on short-term temporal dynamics of functional connectivity. Here, we examined age differences in dynamic connectivity as well as associations between connectivity, metabolic risk, and cognitive performance in healthy adults (N = 168; age, 18-83 years). A sliding-window k-means clustering approach was used to assess dynamic connectivity from resting-state functional magnetic resonance imaging data. Three out of 8 dynamic connectivity profiles were associated with age. Furthermore, metabolic risk was associated with the relative amount of time allocated to 2 of these profiles. Finally, the relative amount of time allocated to a dynamic connectivity profile marked by heightened connectivity between default mode and medial temporal regions was positively associated with executive functions. Thus, dynamic connectivity analyses can enrich understanding of age-related differences beyond what is revealed by static analyses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.