Evidence map›Paper›PMID 28882238›Full record

ReviewJournal of the American College of Cardiology2017

Unraveling Vascular Inflammation: From Immunology to Imaging.

Heather L Teague, Mark A Ahlman, Abass Alavi, Denisa D Wagner, Andrew H Lichtman, Matthias Nahrendorf, Filip K Swirski, Frank Nestle, Joel M Gelfand, Mariana J Kaplan and 6 more

Registry-linked trialAbstract readReview
In one paragraph

Review in Journal of the American College of Cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04046237 (Impact of Treating Severe Periodontitis on Inflammatory Activity of Atheromatous Plaques in Patients With Acute Myocardial Infarction), which is not on this map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04046237 narecruitingnot on this mapstarted 2019, after this paper: background citation

Impact of Treating Severe Periodontitis on Inflammatory Activity of Atheromatous Plaques in Patients With Acute Myocardial Infarction (AMI)

TypeinterventionalSponsorAssistance Publique - Hôpitaux de ParisRan2019 to 2028Enrolled210ConditionsAcute Myocardial Infarction, Severe Periodontitis, Carotid AtherosclerosisArmsPeriodontal treatment
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 68 citations in OpenAlex.

  1. Trial
  2. Article
  3. Aortic Atherosclerosis: An Updated Review of Current Guidelines and Management Approach-A Literature Review.The International journal of angiology : official publication of the International College of Angiology, Inc · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. The application of molecular imaging to advance translational research in chronic inflammation.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Advances in coronary molecular imaging: Leveraging the power of image processing.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020
    Article
  15. Vasculoprotective Effects of Vildagliptin. Focus on Atherogenesis.International journal of molecular sciences · 2020
    Review
  16. Psoriasis and Co-morbidity.Acta dermato-venereologica · 2020
    Review
  17. Emerging techniques in atherosclerosis imaging.The British journal of radiology · 2019
    Review
  18. Association of aortic vascular uptake ofEuropean journal of nuclear medicine and molecular imaging · 2019
    Observational
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 2 countries.

Heather L TeagueNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Mark A AhlmanRadiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Maryland.
Abass AlaviUniversity of Pennsylvania, Philadelphia, Pennsylvania.
Denisa D WagnerHarvard Medical School, Boston, Massachusetts.
Andrew H LichtmanBrigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Matthias NahrendorfCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Filip K SwirskiCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Frank NestleKings College, London, United Kingdom.
Joel M GelfandPerelman School of Medicine, Philadelphia, Pennsylvania.
Mariana J KaplanNational Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland.
Steven GrinspoonProgram in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Paul M RidkerBrigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
David E NewbyBritish Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom.
Ahmed TawakolCardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Zahi A FayadIcahn School of Medicine at Mount Sinai, New York, New York.
Nehal N MehtaCardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address: nehal.mehta@nih.gov.
Harvard University · USBrigham and Women's Hospital · USNational Institutes of Health · USBritish Heart Foundation · GBIcahn School of Medicine at Mount Sinai · USKing's College London · GBNational Institutes of Health Clinical Center · USUniversity of Pennsylvania · US

Funding

Systemic AutoimmunityZIAAR041199 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI KAPLAN, MARIANA · 2014 to 2025
$32.5M
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTOPHER P DUGGAN · 1994 to 2026
$31.6M
Human Translational Studies of Inflammation and Cardiometabolic Diseases: The Psoriasis, Atherosclerosis and Cardiometabolic disease (PACI) InitiativeZIAHL006193 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI SACK, MICHAEL · 2014 to 2023
$25.0M
Ga68-DOTATATE PET imaging of plaque inflammationR01HL135878 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FAYAD, ZAHI A. · 2017 to 2020
$2.9M
Intramural NIH HHS ZIA HL006193NHLBI NIH HHS R01 HL135878NIDDK NIH HHS P30 DK040561
6 · The paper itself

Abstract

Inflammation is a critical factor in early atherosclerosis and its progression to myocardial infarction. The search for valid surrogate markers of arterial vascular inflammation led to the increasing use of positron emission tomography/computed tomography. Indeed, vascular inflammation is associated with future risk for myocardial infarction and can be modulated with short-term therapies, such as statins, that mitigate cardiovascular risk. However, to better understand vascular inflammation and its mechanisms, a panel was recently convened of world experts in immunology, human translational research, and positron emission tomographic vascular imaging. This contemporary review first strives to understand the diverse roles of immune cells implicated in atherogenesis. Next, the authors describe human chronic inflammatory disease models that can help elucidate the pathophysiology of vascular inflammation. Finally, the authors review positron emission tomography-based imaging techniques to characterize the vessel wall in vivo.

Indexed as

Diagnostic ImagingImmunity, InnateCardiovascular DiseasesHumansInflammationRisk FactorsVasculitiscardiovascular imagingmonocytesneutrophilsT cells

Identifiers

PMID28882238
PMCPMC5658004
OpenAlexW2751978257

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.