ArticleArthritis research & therapy2017
Estrogen attenuates the spondyloarthritis manifestations of the SKG arthritis model.
Article in Arthritis research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Causal relationship between endometriosis with infertility and ankylosing spondylitis.Scientific reports · 2023Trial
- Sex differences in clinical and imaging characteristics of axial juvenile spondyloarthritis.Rheumatology (Oxford, England) · 2026Article
- Rebalancing immunity: The emerging role of selective estrogen receptor modulators in immunity and autoimmunity.Current trends in immunology · 2025Article
- Sex Differences and Androgen Regulation Shape Mucosal Immune Phenotype, Gut Microbiota, and Microbiota-Derived Lactate in SKG Arthritis Model.Journal of inflammation research · 2025Article
- Fertility issues in women of childbearing age with spondyloarthritis.Frontiers in immunology · 2024Review
- Revealing mechanism of Methazolamide for treatment of ankylosing spondylitis based on network pharmacology and GSEA.Scientific reports · 2023Article
- Review
- Review
- Single-Cell Genomics for Investigating Pathogenesis of Inflammatory Diseases.Molecules and cells · 2023Review
- Sexual dimorphism in the prevalence, manifestation and outcomes of axial spondyloarthritis.Nature reviews. Rheumatology · 2022Review
- Sex- and gender-related differences in psoriatic arthritis.Nature reviews. Rheumatology · 2022Review
- Spondyloarthritides: Theories and beyond.Frontiers in pediatrics · 2022Review
- Selective estrogen receptor modulator lasofoxifene suppresses spondyloarthritis manifestation and affects characteristics of gut microbiota in zymosan-induced SKG mice.Scientific reports · 2021Article
- The Effects of Sex and Estrogen on Radiographic Progression of Ankylosing Spondylitis in Korean Patients.Journal of rheumatic diseases · 2021Article
- The Emerging Roles of Endocrine Hormones in Different Arthritic Disorders.Frontiers in endocrinology · 2021Review
- Immunopathophysiology of Juvenile Spondyloarthritis (jSpA): The "Out of the Box" View on Epigenetics, Neuroendocrine Pathways and Role of the Macrophage Migration Inhibitory Factor (MIF).Frontiers in medicine · 2021Review
- Genetics, Epigenetics, and Gender Impact in Axial-Spondyloarthritis Susceptibility: An Update on Genetic Polymorphisms and Their Sex Related Associations.Frontiers in genetics · 2021Review
- Can the Second to Fourth Digit Ratio (2D : 4D) Be a Marker to Determine Ankylosing Spondylitis Disease Activity?Disease markers · 2019Article
- Gender Differences in Axial Spondyloarthritis: Women Are Not So Lucky.Current rheumatology reports · 2018Review
- The Role of Flavonoids in Inhibiting Th17 Responses in Inflammatory Arthritis.Journal of immunology research · 2018Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnkylosing spondylitis (AS) is a male-predominant disease, and radiographic evidence of damage is also more severe in males. Estrogen modulates immune-related processes such as T cell differentiation and cytokine production. This study aimed to evaluate the effect of estrogen on the disease activity of spondyloarthritis (SpA).
methodsThe effects of estrogen on the development of arthritis were evaluated by performing ovariectomy and 17β-estradiol (E2) pellet implantation in zymosan-treated SKG mice. Clinical arthritis scores were measured, and
resultsE2-treated mice showed remarkable suppression of arthritis clinically and little infiltration of inflammatory cells in the Achilles tendon and intervertebral disc.
conclusionsEstrogen suppressed arthritis development in SKG mice, a model of SpA. Results of this study suggest that estrogen has an anti-inflammatory effect on the spondyloarthritis manifestations of the SKG arthritis model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.