Evidence map›Paper›PMID 28882142›Full record

ArticleInternational journal for equity in health2017

Prospective associations of psychosocial adversity in childhood with risk factors for cardiovascular disease in adulthood: the MRC National Survey of Health and Development.

Emma L Anderson, Rishi Caleyachetty, Mai Stafford, Diana Kuh, Rebecca Hardy, Debbie A Lawlor, Abigail Fraser, Laura D Howe

Abstract read
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In one paragraph

Article in International journal for equity in health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Dimensions of early life adversity and cardiometabolic health in adulthood: A systematic review and meta-analysis.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026
    Pooled it
  2. Pooled it
  3. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Emma L AndersonMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK. emma.louise.anderson@bristol.ac.uk.
Rishi CaleyachettyThe Institute of Applied Health Research, University of Birmingham, Birmingham, UK.
Mai StaffordMRC Unit for Lifelong Health and Ageing, University College London, London, UK.
Diana KuhMRC Unit for Lifelong Health and Ageing, University College London, London, UK.
Rebecca HardyMRC Unit for Lifelong Health and Ageing, University College London, London, UK.
Debbie A LawlorMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
Abigail FraserMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
Laura D HoweMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.

Funding

Early life adversity and trajectories of cardiometabolic health, cognitive function and physical function: improving understanding of the mechanisms and potential reversibilityR01AG048835 · NIA · UNIVERSITY OF BRISTOL · PI HOWE, LAURA D · 2014 to 2015
$154k
Medical Research Council MC_UU_12013/5Medical Research Council MC_UU_12013/9Medical Research Council MC_UU_12019/1Medical Research Council MC_UU_12019/2Medical Research Council MR/M009351/1Medical Research Council MR/M020894/1Medical Research Council MR/P014437/1NIA NIH HHS R01 AG048835
6 · The paper itself

Abstract

backgroundStudies assessing associations of childhood psychosocial adversity (e.g. sexual abuse, physical neglect, parental death), as opposed to socioeconomic adversity, with cardiovascular disease (CVD) risk factors in adulthood are scarce. We aimed to assess associations of various forms of psychosocial adversity and cumulative adversity in childhood, with multiple CVD risk factors in mid-life.

methodsParticipants were from the MRC National Survey of Health and Development. Childhood psychosocial risk factors were reported prospectively by parents from 1950-1957, and retrospectively by participants at mean age 43 years in 1989. CVD risk factors were assessed at mean age 60-64 years in 2006-2011. Associations of a summary score of total psychosocial adversity and CVD risk in adulthood were assessed.

resultsThere was no consistent evidence that cumulative psychosocial adversity, nor any specific form of psychosocial adversity in childhood, was associated with CVD risk factors in late adulthood. There was some evidence that parental death in the first 15 years was associated with higher SBP (Beta: 0.23, 95% confidence interval: 0.06 to 0.40, P=0.01) and DBP (Beta: 0.15, 95% confidence interval: -0.01 to 0.32, P=0.07).

conclusionsWe found no evidence that exposure to greater psychosocial adversity, or specific forms of psychosocial adversity during childhood is associated with adult CVD risk factors. Further large population studies are needed to clarify whether parental death is associated with higher systolic and diastolic blood pressure.

Indexed as

Life Change EventsCardiovascular DiseasesFemaleHealth SurveysHumansMaleMiddle AgedProspective StudiesRisk FactorsUnited KingdomAdversityCardiovascular diseaseChildhoodPsychosocial

Identifiers

PMID28882142
PMCPMC5590112

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.