ArticleBMC psychiatry2017
TSH cut off point based on depression in hypothyroid patients.
Article in BMC psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 68 citations in OpenAlex.
- Impaired Sustained Attention in Patients with Subclinical Hypothyroidism.Clinical medicine & research · 2025Article
- Assessment of the Correlation Between Unipolar and Bipolar Depression, Calcium Levels, Thyroid Function, and Inflammatory Markers: A Pilot Cross-Sectional Study.Psychopharmacology bulletin · 2025Article
- Associative Learning in Subclinical Hypothyroidism at Different Ranges of Thyroid Stimulating Hormone: A Cambridge Neuropsychological Test Automated Battery (CANTAB) Study of Visual Paired Association Learning Task.Endocrine, metabolic & immune disorders drug targets · 2025Article
- The Assessment of Geriatric Depression Among Primary Healthcare Physicians in Buraidah City, Saudi Arabia.Cureus · 2024Article
- Is the acquired hypothyroidism a risk factor for developing psychiatric disorders?Frontiers in psychiatry · 2024Review
- Thyroid Function Affects the Risk of Post-stroke Depression in Patients With Acute Lacunar Stroke.Frontiers in neurology · 2022Article
- Variation in Thyroid-Stimulating Hormone and Cognitive Disorders in Unmedicated Middle-Aged Patients with Major Depressive Disorder: A Proton Magnetic Resonance Spectroscopy Study.Mediators of inflammation · 2022Article
- Subclinical thyroid dysfunction and major depressive disorder.Hormones (Athens, Greece) · 2021Review
- Effect of yoga on depression in hypothyroidism: A pilot study.Journal of traditional and complementary medicine · 2021Article
- Nicotinic ganglionic acetylcholine receptor autoantibodies associated with paraneoplastic disease in a neuropsychiatric patient.BMJ case reports · 2021Article
- Increased prevalence of subclinical hypothyroidism in female hospitalized patients with depression.Endocrine · 2021Article
- Depression, Metabolic Syndrome, Serum TSH, and Vitamin D Concentrations in Rural and Urban Postmenopausal Women.Medicina (Kaunas, Lithuania) · 2020Article
- Mood Disorders in Levothyroxine-Treated Hypothyroid Women.International journal of environmental research and public health · 2019Article
- The association between anxiety and depression with 25(OH)D and thyroid stimulating hormone levels.Neurosciences (Riyadh, Saudi Arabia) · 2019Article
- Prevalence of depression among hypothyroid patients attending the primary healthcare and endocrine clinics of King Fahad Hospital of the University (KFHU).Journal of family medicine and primary care · 2019Article
- Plasma nesfatin-1 level is associated with severity of depression in Chinese depressive patients.BMC psychiatry · 2018Article
- TSH and T4 Levels in a Cohort of Depressive Patients.Current health sciences journalArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prevalence of depressive symptoms in hypothyroidism is high. Considering that hypothyroidism and depression share some clinical features, some researchers use the "brain hypothyroidism" hypothesis to explain the pathogenesis of depression. We aimed to detect a new TSH cut-off value in hypothyroidism based on depression symptoms.
methodsA cross-sectional study was conducted on hypothyroid patients referred to endocrine clinics. Individuals who had developed euthyroid state under treatment with levothyroxine with TSH levels of 0.5-5 MIU/L with no need for dosage change were included in the study. After comprehensive history taking, laboratory tests including TSH, T4 and T3 were performed. Beck depression questionnaire was completed for all patients by trained interviewers. TSH cut-off values based on depression was determined by Roc Curve analysis.
resultsThe participants were 174 hypothyroid patients (Female; 116: 66.7%, Male; 58: 33.3%) with mean age 45.5 ± 11.7 (19-68) years old. Based on Beck depression test, scores less than 10 was considered healthy and more than 10 were considered depressed. According to Roc curve analysis, the optimal cut- off value of TSH was 2.5 MIU/L with 89.66% sensitivity. The optimal TSH cut- off based on severe depression was 4 MIU/L.
conclusionThe present study suggests that a clinically helpful TSH cut-off value for hypothyroidism should be based on associated symptoms, not just in population studies. Based on the assessment of depression, our study concludes that a TSH cutofff value of 2.5 MIU/L is optimal.
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