Evidence map›Paper›PMID 28882061›Full record

Trial reportClinical rehabilitation2018

Feasibility of a home-based exercise intervention with remote guidance for patients with stable grade II and III gliomas: a pilot randomized controlled trial.

Karin Gehring, Corelien Jj Kloek, Neil K Aaronson, Kasper W Janssen, Lee W Jones, Margriet M Sitskoorn, Martijn M Stuiver

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical rehabilitation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 13 syntheses or guidelines pooled it.

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  13. Efficacy of Exercise Therapy on Cardiorespiratory Fitness in Patients With Cancer: A Systematic Review and Meta-Analysis.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2018
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  16. Multimodal exercise ameliorates exercise responses and body composition in head and neck cancer patients receiving chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Karin Gehring1 Department of Cognitive Neuropsychology, Tilburg University, Tilburg, The Netherlands.
Corelien Jj Kloek1 Department of Cognitive Neuropsychology, Tilburg University, Tilburg, The Netherlands.
Neil K Aaronson4 Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Kasper W Janssen5 Department of Sports and Exercise Medicine, Gelderse Vallei Hospital, Ede, The Netherlands.
Lee W Jones6 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Margriet M Sitskoorn1 Department of Cognitive Neuropsychology, Tilburg University, Tilburg, The Netherlands.
Martijn M Stuiver7 Department of Physical Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

objectiveIn this pilot study, we investigated the feasibility of a home-based, remotely guided exercise intervention for patients with gliomas.

designPilot randomized controlled trial (RCT) with randomization (2:1) to exercise or control group. SUBJECTS: Patients with stable grade II and III gliomas.

interventionThe six-month intervention included three home-based exercise sessions per week at 60%-85% of maximum heart rate. Participants wore heart rate monitors connected to an online platform to record activities that were monitored weekly by the physiotherapist. MAIN MEASURES: Accrual, attrition, adherence, safety, satisfaction, patient-reported physical activity, VO

resultsIn all, 34 of 136 eligible patients (25%) were randomized to exercise training ( N = 23) or the control group ( N = 11), of whom 19 and 9, respectively, underwent follow-up. Mean adherence to prescribed sessions was 79%. Patients' experiences were positive. There were no adverse events. Compared to the control group, the exercise group showed larger improvements in absolute VO

conclusionThis innovative and intensive home-based exercise intervention was feasible in a small subset of patients with stable gliomas who were interested in exercising. The observed effects suggest that the programme may improve cardiorespiratory fitness. These results support the need for large-scale trials of exercise interventions in brain tumour patients.

Indexed as

AgedBrain NeoplasmsExercise TherapyFeasibility StudiesFemaleGaitGliomaHome Care ServicesHumansMaleMiddle AgedNetherlandsPilot ProjectsPostural BalanceQuality of LifeRisk Assessmentbrain tumourexerciseGliomaphysical fitnessphysical training

Identifiers

PMID28882061
PMCPMC6625754

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.