ArticleJournal of the American Chemical Society2017
Host-Guest Tethered DNA Transducer: ATP Fueled Release of a Protein Inhibitor from Cucurbit[7]uril.
Article in Journal of the American Chemical Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- An Engineered Supramolecular Pathway for Enhanced Electrochemiluminescence.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Cucurbit[6]uril-monoazide: towards functional CB[6]-tethered DNA (pseudo)rotaxanes.Chemical science · 2026Article
- Controlled assembly of exogenous DNA-based materials in living cells.Fundamental research · 2026Review
- Supramolecularly gated enzymes: On-demand activity switching via host-guest competition for precision tumor therapy.Materials today. Bio · 2026Article
- Supramolecular delivery of dinuclear ruthenium and osmium MCU inhibitors.Inorganic chemistry frontiers · 2024Article
- Reversible Control of Gene Expression by Guest-Modified Adenosines in a Cell-Free System via Host-Guest Interaction.Journal of the American Chemical Society · 2024Article
- High-Affinity Host-Guest Recognition for Efficient Assembly and Enzymatic Responsiveness of DNA Nanostructures.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- Overcoming barriers with non-covalent interactions: supramolecular recognition of adamantyl cucurbit[RSC medicinal chemistry · 2024Review
- Challenges and Opportunities of Functionalized Cucurbiturils for Biomedical Applications.JACS Au · 2023Review
- Chemically programmable bacterial probes for the recognition of cell surface proteins.Materials today. Bio · 2023Article
- Controllable DNA hybridization by host-guest complexation-mediated ligand invasion.Nature communications · 2022Article
- DNA Strand Displacement Driven by Host-Guest Interactions.Journal of the American Chemical Society · 2022Article
- DNA Nanodevice-Based Drug Delivery Systems.Biomolecules · 2021Review
- Article
- Multiplexed optical barcoding of cellsChemical science · 2021Article
- Carborane Guests for Cucurbit[7]uril Facilitate Strong Binding and On-Demand Removal.Journal of the American Chemical Society · 2020Article
- Decorating bacteria with self-assembled synthetic receptors.Nature communications · 2020Article
- Chaperone-Assisted Host-Guest Interactions Revealed by Single-Molecule Force Spectroscopy.Journal of the American Chemical Society · 2019Article
- A Sample Preparation Technique Using Biocompatible Composites for Biomedical Applications.Molecules (Basel, Switzerland) · 2019Article
- Molecular Logic as a Means to Assess Therapeutic Antidotes.Frontiers in chemistry · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Host-guest complexes are emerging as powerful components in functional systems with applications ranging from materials to biomedicine. In particular, CB7 based host-guest complexes have received much attention for the controlled release of drugs due to the remarkable ability of CB7 toward binding input molecules in water with high affinity leading to displacement of CB7 from included pharmacophores (or from drug loaded porous particles). However, the release of bound guests from CB7 in response to endogenous biological molecules remains limited since the input biomolecule needs to have the appropriate chemical structure to bind tightly into the CB7 cavity. Herein we describe a synthetic transducer based on self-assembling DNA-small molecule chimeras (DCs) that is capable of converting a chosen biological input, adenosine triphosphate (ATP; that does not directly bind to the CB7 host), into functional displacement of a protein inhibitor that is bound within the CB7 host. Our system-which features the first example of a covalent CB-DNA conjugate-is highly modular and can be adapted to enable responsiveness to other biologically/clinically relevant stimuli via its split DNA aptamer architecture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.